20703-96-2Relevant academic research and scientific papers
Stereocontrolled oxycarbonylation of 4-benzyloxyhepta-1,6-diene-3,5-diols promoted by chiral palladium(II) complexes
Kapitan, Peter,Gracza, Tibor
, p. 38 - 44 (2008)
The synthesis of all diastereomers of 4-benzyloxyhepta-1,6-diene-3,5-diols 8-10 is described. The diastereo- and enantioselectivity of palladium(II)-catalysed oxycarbonylation of the symmetric compounds 8-10 were studied. The substrates 8-10 underwent Pd(II)-initiated oxycarbonylative bicyclisation to afford bicyclic lactones 11-14 in good yields and with excellent threo-diastereoselectivity. Additionally, the synthesis of enantiomerically pure lactone d-gluco-12, precursor for syntheses of goniofufurone and 7-epi-goniofufurone, was developed.
A convenient synthesis of N-substituted trihydroxypiperidines from bis- epoxides: Nucleophilic opening of 1,2:4,5-dianhydropentitols
Smith, Rachel D.,Thomas, Neil R.
, p. 193 - 196 (2007/10/03)
Synthesis of a number of N-substituted trihydroxypiperidine and trihydroxypyrrolidines is described via the nucleophilic opening and cyclisation of suitable bis-epoxides. Reaction conditions to maximise the yield of the trihydroxypiperidine products forme
