207113-20-0

Upstream product

• 76693-57-7 (4-bromophenyl)(p-tolyl)methanone 
• 88641-79-6 tert-butyl 4-(4'-bromomethylbenzoyl)perbenzoate 
• 71-43-2 benzene 

Downstream Products

• 207113-21-1 [4-(4-Bromo-benzoyl)-phenyl]-acetonitrile 
• 207113-24-4 [4-(4-Cyano-benzoyl)-phenyl]-acetic acid 2,5-dioxo-pyrrolidin-1-yl ester 
• 207113-23-3 [4-(4-Cyano-benzoyl)-phenyl]-acetic acid 
• 207113-22-2 [4-(4-Bromo-benzoyl)-phenyl]-acetic acid 

Relevant academic research and scientific papers

IMIDAZOPYRROLOPYRIDINE AS INHIBITORS OF THE JAK FAMILY OF KINASES

2-((1r,4r)-4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions mediated by JAK, such as inflammatory bowel disease.

Triplet energy distribution in photoinitiators containing two dissociable groups

Suitable probe molecules containing the benzophenone chromophore and one dissociable bond [perester 1 or C-X (4, 5)] or two such bonds (2, 3) have been synthesized and studied to examine intramolecular triplet energy dispersion. Triplet energies and phosphorescence quantum yields as well as quantum efficiencies of bond scissions have been studied, and the flow of triplet energy in such molecules is discussed. Upon irradiation at 350 nm in either benzene or methanol, the target peresters undergo dissociation of both cleavable groups, producing a pair of radicals. The presence of a benzylic chloride function has little influence on the efficiency of perester dissociation. However, the presence of a benzylic bromide function was found to decrease the quantum yield of decomposition of the perester function of 3. This can be explained by taking into account the effect of the heavy atom and the rate of cage geminate radical pair recombination. The nature of the heavy atom perturbation, however, was found to be different in 5 as compared with 3.

p-cyano substituted benzophenone as an excellent photophore for one- electron oxidation of DNA

Novel DNA-photocleaving molecule 1 consisting of a p-cyano substituted benzophenone photophore and an alkyl amino side chain was developed. DNA cleavage by 1 under photoirradiation conditions occurred selectively at 5' side G of 5'GG3' sequence after hot