207120-60-3Relevant academic research and scientific papers
Discovery of the first potent and selective αvβ5 integrin inhibitor based on an amide-containing core
Lippa, Rhys A.,Barrett, John,Pal, Sandeep,Rowedder, James E.,Murphy, John A.,Barrett, Tim N.
, (2020)
Integrins αvβ5 and αvβ3 are closely related, proangiogenic members of the wider RGD-binding integrin family. Due to their high sequence homology, the development of αvβ5-selective compounds
Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
-
, (2008/06/13)
The present invention is directed to compound of the formula I: STR1 wherein R1, R2, R3, R4, R5, X, Y, and STR2 are as defined herein. These compounds are useful for inhibiting the activity of a metalloproteinase by contacting the metalloproteinase with an effective amount of the inventive compounds.
