207124-17-2

Upstream product

• 207124-05-8 (2S,3R)-2-Benzyloxy-3,4-dihydroxy-butyric acid methyl ester 
• 120383-54-2 (2S)-benzyloxy-[(4S)-2,2-dimethyl-[1,3]dioxolan-4-yl]-acetic acid methyl ester 
• 207124-06-9 (2S,3R)-2-Benzyloxy-4-(tert-butyl-diphenyl-silanyloxy)-3-hydroxy-butyric acid methyl ester 
• 207124-10-5 methyl (R)-4-(tert-butyldiphenylsilyl)oxy-3-[3-(methoxymethoxy)propionyl]oxy-2-oxobutanoate 
• 207124-09-2 (2S,3R)-4-(tert-Butyl-diphenyl-silanyloxy)-2-hydroxy-3-(3-methoxymethoxy-propionyloxy)-butyric acid methyl ester 
• 207124-08-1 (2S,3R)-2-Benzyloxy-4-(tert-butyl-diphenyl-silanyloxy)-3-(3-methoxymethoxy-propionyloxy)-butyric acid methyl ester 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 207124-12-7 4-ethyl 1-methyl [2S,2(1R)]-2-[2-(tert-butyldiphenylsilyl)oxy-1-[3-(methoxymethoxy)propionyl]oxyethyl]-3-diazo-2-hydroxybutanediote 

Relevant academic research and scientific papers

Total syntheses of zaragozic acids A and C by a carbonyl ylide cycloaddition strategy

A carbonyl ylide cycloaddition approach to the squalene synthase inhibitors zaragozic acids A and C is described. The carbonyl ylide precursor 8 was synthesized starting from di-tert-butyl D-tartrate (47) via an eleven-step sequence involving the regiosel

Toward the second-generation synthesis of zaragozic acids: Construction of the 2,8-dioxabicyclo[3.2.1]octane core system via tandem carbonyl ylide formation and 1,3-dipolar cycloaddition sequence

A highly efficient construction of the 2,8-dioxabicyclo[3.2.1]octane core structure of zaragozic acids, inhibitors of the enzyme squalene synthase, has been achieved by exploiting the sequence of rhodium(II)- mediated intramolecular carbonyl ylide formati