207129-51-9Relevant academic research and scientific papers
The synthesis and evaluation of cyclic ureas as HIV protease inhibitors: Modifications of the P1/P1' residues
Patel, Mona,Bacheler, Lee T.,Rayner, Marlene M.,Cordova, Beverly C.,Klabe, Ronald M.,Erickson-Viitanen, Susan,Seitz, Steven P.
, p. 823 - 828 (2007/10/03)
Two series of cyclic ureas modified at the P1/P1' residue were prepared and evaluated for HIV protease inhibition and whole cell antiviral activity. Compounds 8b, 10 (3- and 4-pyridylmethyl analogs) and 6b (4-methoxy analog) showed significant improvement in antiviral activity relative to lead compounds DMP323 and DMP450.
