207235-82-3Relevant articles and documents
Synthesis, structure - Activity relationships, and pharmacokinetic profiles of nonpeptidic α-keto heterocycles as novel inhibitors of human chymase
Akahoshi,Ashimori,Sakashita,Yoshimura,Eda,Imada,Nakajima,Mitsutomi,Kuwahara,Ohtsuka,Fukaya,Miyazaki,Nakamura
, p. 1286 - 1296 (2007/10/03)
We designed nonpeptidic chymase inhibitors based on the structure of a peptidic compound (1) and demonstrated that the combination of a pyrimidinone skeleton as a P3-P2 scaffold and heterocycles as P1 carbonyl-activating g