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Usage

Uses

Used in Organic Synthesis:
2'-C-Methylcytidine is utilized as a compound in organic synthesis for the development of new chemical entities and pharmaceuticals.
Used in Pharmaceutical Industry:
2CMC is used as an antiviral agent for its ability to reduce viral plaques and inhibit replication of multiple RNA viruses, offering potential therapeutic benefits in treating viral infections.
Used in Antiviral Research:
In the field of antiviral research, 2'-C-Methylcytidine serves as a valuable compound for studying its mechanism of action and exploring its potential as a broad-spectrum antiviral treatment.
Used in Viral Infection Prevention:
2CMC is used as a preventative measure to protect cells from viral infections, as evidenced by its protective effects on MDBK cells from bovine virus diarrhea virus and human coronavirus infections.
Used in In Vivo Antiviral Models:
2'-C-Methylcytidine is applied in in vivo models, such as the mouse model of persistent norovirus infection, to study its efficacy in reducing viral shedding and assessing its potential for clinical use.

Biochem/physiol Actions

2′-C-Methylcytidine is a potent inhibitor of the HCV NS5B RNA polymerase. 2′-C-Methylcytidine was the first nucleoside NS5B inhibitor that showed clinical efficacy. 2′-C-Methylcytidine was found to be effective against the 17D vaccine strain of yellow fever virus YFV in cell culture.

Upstream product

• 23643-36-9 2′,3′,5′-tri-O-benzoyl-2′-C-methyluridine 

Downstream Products

• 914912-07-5 5-O-(4-chlorophenyl methoxydimethylglycinylphosphate)-(2-C-methyl-β-D-ribofuranosyl)cytosine 
• 946511-13-3 ethyl (2S)-2-{[{[(2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl]methoxy}(4-chlorophenoxy)phosphoryl]amino}propanoate 
• 946511-63-3 5'-O-[[[(1S)-1-methyl-2-(1-methylethoxy)-2-oxoethyl]amino]phenoxyphosphinyl]-2'-C-methylcytidine 
• 946511-76-8 5'-O-[(4-chlorophenoxy)[(2-methoxy-2-oxoethyl)amino]phosphinyl]-2'-C-methylcytidine 
• 946511-72-4 5'-O-[(4-chlorophenoxy)[[(1S)-1-(ethoxycarbonyl)-3-methylbutyl]amino]phosphinyl]-2'-C-methylcytidine 
• 946511-74-6 5'-O-[(4-chlorophenoxy)[[(1S)-1-(ethoxycarbonyl)pentyl]amino]phosphinyl]-2'-C-methylcytidine 
• 1185923-59-4 5'-O-[(4-chlorophenoxy)[(3-methoxy-3-oxopropyl)amino]phosphinyl]-2'-C-methylcytidine 
• 1185923-61-8 5'-O-[(4-chlorophenoxy)[[(1R)-2-methoxy-1-methyl-2-oxoethyl]amino]phosphinyl]-2'-C-methylcytidine 
• 1185923-63-0 5'-O-[(4-chlorophenoxy)[[(1S)-2-methoxy-2-oxo-1-(phenylmethyl)ethyl]amino]phosphinyl]-2'-C-methylcytidine 
• 946511-78-0 5'-O-[(4-chlorophenoxy)[[(1S)-2-ethoxy-2-oxo-1-phenylethyl]amino]phosphinyl]-2'-C-methylcytidine 
• 946511-81-5 5'-O-[(4-chlorophenoxy)[[(1S)-2-ethoxy-1-(1H-indol-3-ylmethyl)-2-oxoethyl]amino]phosphinyl]-2'-C-methylcytidine 
• 946511-45-1 5'-O-[[[(1S)-2-butoxy-1-methyl-2-oxoethyl]amino](2-chlorophenoxy)phosphinyl]-2'-C-methylcytidine 
• 946511-59-7 5'-O-[[[(1S)-2-ethoxy-1-methyl-2-oxoethyl]amino](2-methylphenoxy)phosphinyl]-2'-C-methylcytidine 
• 1185923-76-5 5'-O-[[4-chloro-5-methyl-2-(1-methylethyl)phenoxy][[(1S)-2-ethoxy-1-methyl-2-oxoethyl]amino]phosphinyl]-2'-C-methylcytidine 

Relevant academic research and scientific papers

NM 283, an efficient prodrug of the potent anti-HCV agent 2′-C-methylcytidine

In order to improve the oral bioavailability of 2′-C-methylcytidine, a potent anti-HCV agent, the corresponding 3′-O-L-valinyl ester derivative (NM 283) has been synthesized. Based on its ease of synthesis and its physicochemical properties, NM 283 has emerged as a promising antiviral drug for treatment of chronic HCV infection. Copyright Taylor & Francis, Inc.