207290-72-0

Basic information

• Product Name: 5-(4-Hydroxypiperidino)-2-thiophenecarbaldehyde
• Synonyms: 5-(4-Hydroxypiperidino)-2-Thio;5-(4-Hydroxypiperidino)-2-thiophenecarbaldehyde;2-Formyl-5-(4-hydroxypiperidin-1-yl)thiophene, 1-(5-Formylthien-2-yl)-4-hydroxypiperidine;5-(4-hydroxypiperidin-1-yl)thiophene-2-carbaldehyde;5-(4-Hydroxy-1-piperidinyl)-2-thiophenecarboxaldehyde
• CAS NO: 207290-72-0
• Molecular Formula: C10H13NO2S
• Molecular Weight: 211.28
• Product Categories: Piperidine;Thiophene intermediates
• Mol File: 207290-72-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 137-139°
• Boiling Point: 417.8 °C at 760 mmHg
• Flash Point: 206.5 °C
• Appearance: /
• Density: 1.321 g/cm³
• Vapor Pressure: 9.97E-08mmHg at 25°C
• Refractive Index: 1.642
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 14.77±0.20(Predicted)
• CAS DataBase Reference: 5-(4-Hydroxypiperidino)-2-thiophenecarbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-Hydroxypiperidino)-2-thiophenecarbaldehyde(207290-72-0)
• EPA Substance Registry System: 5-(4-Hydroxypiperidino)-2-thiophenecarbaldehyde(207290-72-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 207290-72-0(Hazardous Substances Data)

Usage

General Description

5-(4-Hydroxypiperidino)-2-thiophenecarbaldehyde is a chemical compound with the molecular formula C11H13NO2S. It is an aldehyde compound containing a piperidino group and a thiophene ring. The presence of the hydroxy group in the piperidine ring and the aldehyde functional group makes this compound a potential intermediate in the synthesis of various organic compounds. This chemical may have applications in medicinal chemistry, organic synthesis, and potentially other industrial processes. Further research and evaluation of its properties and potential uses are needed to fully understand the capabilities of this compound.

InChI:InChI=1/C10H13NO2S/c12-7-9-1-2-10(14-9)11-5-3-8(13)4-6-11/h1-2,7-8,13H,3-6H2

Upstream product

• 5382-16-1 4-HYDROXYPIPERIDINE 
• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 

Downstream Products

• 912287-56-0 (Z)-2-(3,4-dimethoxy-phenyl)-3-[5-(4-hydroxy-piperidin-1-yl)-thiophen-2-yl]-acrylonitrile 

Relevant articles and documents

Efficient synthesis of N,N-disubstituted 5-aminothiophene-2-carboxaldehydes by nucleophilic aromatic substitution in water

We have developed the first synthesis of N,N-disubstituted 5-aminothiophene-2-carboxaldehydes by Nucleophilic Aromatic Substitution of 5-bromothiophene-2-carboxaldehyde in water. This study shows selectivity between primary and secondary amines leading to

Synthesis of high molar extinction coefficient push-pull tricyanofuran-based disperse dyes: Biological activity and dyeing performance

Several push-pull tricyanofuran-based disperse dyes with high molar extinction coefficient were synthesized and fully characterized. The dyes were preparedviaKnoevenagel reaction in dry pyridine under ambient conditions employing acetic acid as catalyst. The condensation process was carried out between the reactive methyl-bearing tricyanofuran moiety and tertiary amine-based arylaldehyde. The molecular structures of the synthesized chromophores were proved by Fourier transform infrared spectroscopy (FT-IR), nuclear magnetic resonance spectroscopy (1H and13C NMR) and elemental analysis (C, H, N). The UV-Vis absorbance spectra of the synthesized dyes demonstrated interesting extinction coefficient values, which were found to be influenced by the aromatic-vinyl bridge and the tertiary amine donor group bonded to this aromatic-vinyl bridge moiety. The prepared tricyanofuran-based disperse colorants were dyed on polyester fabrics to afford satisfactory results. The substituents attached to the tertiary amine moiety influenced the absorption maxima. The fastness properties of the dyed polyester samples were measured. The biological activities of the synthesized dyestuffs against fungus (Candida Albican) as well as Gram-positive (S. Aureus) and Gram-negative (E. Coli) pathogens were also evaluated.

BCRP/ABCG2 INHIBITOR

The present invention is directed to a breast cancer resistance protein (BCRP/ABCG2) inhibitor. The BCRP inhibitor contains, as an active ingredient, an acrylonitrile derivative represented by formula (1): wherein one of R1 and R2 re