207298-21-3Relevant articles and documents
Ti(O iPr)4-Enabled Dual Photoredox and Nickel-Catalyzed Arylation and Alkenylation of Cyclopropanols
Varabyeva, Nastassia,Barysevich, Maryia,Aniskevich, Yauhen,Hurski, Alaksiej
supporting information, p. 5452 - 5456 (2021/07/21)
Readily available from esters or ketones, cyclopropanols are inclined to undergo diverse ring-opening transformations. Their one-electron oxidation is a conventional way to β-carbonyl radicals. However, despite this fact, their application as a coupling partner in dual photoredox and nickel-catalyzed reactions with organic halides remains underdeveloped. Here, we report that the Ti(OiPr)4 additive enables this elusive cross-coupling with aryl and alkenyl bromides leading to β-substituted ketones.