207298-22-4

Basic information

• Product Name: 1-[4-(1-hydroxycyclopropyl)butyl]cyclopropan-1-ol
• Synonyms: 1-[4-(1-hydroxycyclopropyl)butyl]cyclopropan-1-ol
• CAS NO: 207298-22-4
• Molecular Formula: C₁₀H₁₈O₂
• Molecular Weight: 170.24872
• Mol File: 207298-22-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-[4-(1-hydroxycyclopropyl)butyl]cyclopropan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(1-hydroxycyclopropyl)butyl]cyclopropan-1-ol(207298-22-4)
• EPA Substance Registry System: 1-[4-(1-hydroxycyclopropyl)butyl]cyclopropan-1-ol(207298-22-4)

Safety Data

• Hazardous Substances Data: 207298-22-4(Hazardous Substances Data)

Upstream product

• 141-28-6 diethyl adipate 
• 925-90-6 ethylmagnesium bromide 

Downstream Products

• 1236206-64-6 1-{(4S)-5-[(4S)-4-benzyl-2-oxooxazolidin-3-yl]-4-methyl-5-oxopentyl}cyclopropyl pivaloate 
• 1258847-18-5 1-{5-[(4S)-4-benzyl-2-oxooxazolidin-3-yl]-5-oxopentyl}cyclopropyl pivaloate 

Relevant articles and documents

Total synthesis of epothilone D by sixfold ring cleavage of cyclopropanol intermediates

The ring-opening or ring fragmentation reactions of cyclopropanol intermediates are used in the total synthesis of epothilone D for the creation of trisubstituted double bonds, an ethyl ketone functionality, as well as for the protection of carboxylic and ester groups. Epothilone D is obtained in 1.6% overall yield (24 steps in the longest linear sequence) starting from (R)-methyl 2,3-O-isopropylideneglycerate. The key cyclopropanol intermediates are efficiently obtained by titanium(IV)-catalyzed reactions of readily available esters with Grignard reagents. Crown Copyright