2073-32-7

Usage

Uses

Used in Pharmaceutical Industry:
Hexahydro-3-methyl-2H-azepin-2-one is used as a key intermediate in the synthesis of RSV (Respiratory Syncytial Virus) inhibitors. These inhibitors play a crucial role in the development of antiviral drugs that help combat respiratory infections caused by the RSV virus.
Used in Polymer Industry:
In the polymer industry, Hexahydro-3-methyl-2H-azepin-2-one is utilized in the preparation of Nylon 6 fibers through caprolactam polymerization. Nylon 6 is a widely used synthetic polymer known for its strength, durability, and resistance to various environmental factors, making it suitable for a range of applications, including textiles, automotive parts, and electrical components.
By understanding the description and uses of Hexahydro-3-methyl-2H-azepin-2-one, we can appreciate its significance in both the pharmaceutical and polymer industries, where it contributes to the development of essential products and materials.

Upstream product

• 7664-93-9 sulfuric acid 
• 583-60-8 2-Methylcyclohexanone 
• 105-60-2 caprolactam 
• 74-88-4 methyl iodide 
• 137897-39-3 2-methyl-1-triisopropylsilyl(oxy)-cyclohex-1-ene 
• 1122-26-5 2-methylcyclohexanone oxime 

Downstream Products

• 150989-49-4 C₂₁H₂₅NO₂S 

Relevant academic research and scientific papers

Direct and Catalytic Amide Synthesis from Ketones via Transoximation and Beckmann Rearrangement under Mild Conditions

The Br?nsted acid-catalyzed synthesis of secondary amides from ketones under mild conditions is described via transoximation and Beckmann rearrangement using O-protected oximes as more stable equivalents of explosive O-protected hydroxylamines. This methodology could be applied to highly rearrangement-selective amide synthesis from α-branched alkyl aryl ketones and performed on a 1-g scale. The presence of water is essential for this reaction, and its role was clarified by isotope-labeling experiments.

COMPOUNDS FOR TREATING DISORDERS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR 5, AND METHODS OF USE THEREOF

Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

Amidino derivatives useful as nitric oxide synthase inhibitors

The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.

Amidino dervatives useful as nitric oxide synthase inhibitors

The current invention discloses useful pharmaceutical compositions containing azepine derivatives useful as nitric oxide synthase inhibitors.

Nitrogen Bridgehead Compounds. 66. Bronchodilator Nitrogen Bridgehead Compounds with a Pyrimidinone Moiety

New types of bronchodilator agents, bi- and tricyclic nitrogen bridgehead compounds with a pyrimidin-4(3H)-one ring, were synthesized and evaluated for bronchodilator activity against serotonin-, histamine-, and acetylcholine-induced spasms in the guinea pig Konzett-Roessler test.The structure-activity relationships are discussed.The effects of some bi- and tricyclic derivatives on the human bronchus were also investigated.The homologous tricyclic compounds 68 and 69 were tested on isolated guinea pig ileum and trachea, and the effects of compound 69 were investigated in pilocarpine-treated dogs.Azepinoquinazoline (69;CHINOIN-1289) was selected for further biochemical and clinical investigations.