2073-59-8

Basic information

• Product Name: ethyl N-[(benzyloxy)carbonyl]glycylphenylalanylglycinate
• CAS NO: 2073-59-8
• Molecular Formula: C₂₃H₂₇N₃O₆
• Molecular Weight: 441.477
• Mol File: 2073-59-8.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 723.3°C at 760 mmHg
• Flash Point: 391.2°C
• Density: 1.227g/cm³
• Vapor Pressure: 8.99E-21mmHg at 25°C
• Refractive Index: 1.56
• CAS DataBase Reference: ethyl N-[(benzyloxy)carbonyl]glycylphenylalanylglycinate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl N-[(benzyloxy)carbonyl]glycylphenylalanylglycinate(2073-59-8)
• EPA Substance Registry System: ethyl N-[(benzyloxy)carbonyl]glycylphenylalanylglycinate(2073-59-8)

Safety Data

• Hazardous Substances Data: 2073-59-8(Hazardous Substances Data)

Upstream product

• 1170-76-9 Z-Gly-(L)-Phe 
• 2949-22-6 Glycine ethyl ester isocyanate 
• 623-33-6 glycine ethyl ester hydrochloride 
• 6306-52-1 L-valine methylester hydrochloride 
• 1330059-32-9 N-benzyloxycarbonylglycine-L-phenylalanine 9-fluorenylmethyl thioester 
• 91586-88-8 ZGlyPhe, triethylammonium salt 
• 459-73-4 GlyOEt*HCl 
• 42567-71-5 L-Phe-Gly-OEt 
• 77374-24-4 C₁₁H₁₆BNO₄*ClH 
• 77374-26-6 C₂₁H₂₅BN₂O₇ 
• 77374-27-7 C₁₉H₂₁BN₂O₇ 
• 76410-58-7 p-borono-L-phenylalanine 
• 2778-34-9 ethyl [(2S)-2-(benzyloxycarbonylamino)-3-phenylpropanoylamino]acetate 
• 501-53-1 benzyl chloroformate 

Relevant articles and documents

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Processes for forming amide bonds and compositions related thereto

The disclosure relates to methods for producing amide bonds and reagents related thereto. In some embodiments, the disclosure relates to methods of producing an amide comprising mixing an O-silylated thionoester and an amine under conditions such that an amide is formed. In another embodiment, the disclosure relates to mixing a thiolacid, a silylating agent, and an amine under conditions such that an amide is formed.

Condensation between isocyanates and carboxylic acids in the presence of 4-dimethylaminopyridine (DMAP), a mild and efficient synthesis of amides

A mild and convenient method for the preparation of amides from carboxylic acids and isocyanates is described. By using DMAP as a catalyst milder reaction conditions are realised which also allow the conversion of α-chiral isocyanates, as well as α-chiral carboxylic acids without racemisation.