207444-89-1Relevant articles and documents
Syntheses of HIV-protease inhibitors having a peptide moiety which binds to GP120
Asagarasu, Akira,Uchiyama, Taketo,Achiwa, Kazuo
, p. 697 - 703 (1998)
Some HIV-protease inhibitor derivatives having an N- carbomethoxycarbonyl-prolyl-phenylalanine benzyl ester (CPF) moiety as a binding site to gp120 were designed and synthesized. Almost all the compounds bearing CPF on the phenoxyacetyl group showed protease-inhibitory activity. Compounds 25a and 25b, which have the CPF moiety at the ortho- and meta- positions of the phenoxyacetyl group, respectively, had anti-HIV activity, although the others showed only protease-inhibitory activity. These results suggest that 25b binds to gp120 and inhibits HIV protease.
Quantitative helix handedness bias through a single Hvs.CH3stereochemical differentiation
Bindl, Daniel,Heinemann, Elisabeth,Mandal, Pradeep K.,Huc, Ivan
supporting information, p. 5662 - 5665 (2021/06/16)
A novel chiral aromatic δ-amino acid building block was shown to fully induce handedness in quinoline oligoamide foldamers with the possibility of further increasing the bias by combining multiples of these units in the same sequence. Through its incorporation within the helix, both N- and C-termini are still accessible for further functionalisation.
GLYCINE B ANTAGONISTS
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Page/Page column 69-70, (2010/12/29)
The invention relates to naphthalene derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are glycine B antagonists and are therefore useful for the control and prevention of various disorders, including neurological disorders.
CARBOXYALKOXY-SUBSTITUTED ACYL-CARBOXYPHENYL-UREA DERIVATIVES, PRODUCTION METHOD AND USE THEREOF AS MEDICINE
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Page/Page column 21, (2008/06/13)
The invention concerns carboxyalkoxy-substituted acyl-carboxyphenyl-urea derivatives of formula (I) wherein the groups are such as defined in the description and their physiologically acceptable salts and their physiologically functional derivatives. The