207444-95-9

Upstream product

• 207444-91-5 tert-butyl [4-(3-hydroxypropyl)phenoxy]acetate 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 207444-93-7 {4-[3-(Toluene-4-sulfonyloxy)-propyl]-phenoxy}-acetic acid tert-butyl ester 
• 10210-17-0 3-(4-hydroxyphenyl)propan-1-ol 

Downstream Products

• 207444-96-0 tert-butyl [4-(3-aminopropyl)phenoxy]acetate 
• 207444-97-1 {4-[3-((R)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-propyl]-phenoxy}-acetic acid tert-butyl ester 
• 207444-98-2 ((S)-2-{(R)-1-[3-(4-tert-Butoxycarbonylmethoxy-phenyl)-propylcarbamoyl]-2-phenyl-ethylcarbamoyl}-pyrrolidin-1-yl)-oxo-acetic acid methyl ester 

Relevant academic research and scientific papers

Syntheses of HIV-protease inhibitors having a peptide moiety which binds to GP120

Some HIV-protease inhibitor derivatives having an N- carbomethoxycarbonyl-prolyl-phenylalanine benzyl ester (CPF) moiety as a binding site to gp120 were designed and synthesized. Almost all the compounds bearing CPF on the phenoxyacetyl group showed protease-inhibitory activity. Compounds 25a and 25b, which have the CPF moiety at the ortho- and meta- positions of the phenoxyacetyl group, respectively, had anti-HIV activity, although the others showed only protease-inhibitory activity. These results suggest that 25b binds to gp120 and inhibits HIV protease.