207447-47-0Relevant academic research and scientific papers
Small-sized human immunodeficiency virus type-1 protease inhibitors containing allophenylnorstatine to explore the s2′ pocket
Hidaka, Koushi,Kimura, Tooru,Abdel-Rahman, Hamdy M.,Nguyen, Jeffrey-Tri,McDaniel, Keith F.,Kohlbrenner, William E.,Molla, Akhteruzzaman,Adachi, Motoyasu,Tamada, Taro,Kuroki, Ryota,Katsuki, Noriko,Tanaka, Yoshiaki,Matsumoto, Hikaru,Wang, Jun,Hayashi, Yoshio,Kempf, Dale J.,Kiso, Yoshiaki
experimental part, p. 7604 - 7617 (2010/05/18)
A series of HIV protease inhibitor based on the allophenylnorstatine structure with various P2′ moieties were synthesized. Among these analogues, we discovered that a small allyl group would maintain potent enzyme inhibitory activity compared t
