207454-82-8

Upstream product

• 773-64-8 2-mesitylenesulphonyl chloride 
• 207454-81-7 (2R,3S,4S)-3,4-Dihydroxy-2-((1R,2S,3R)-1,2,3,4-tetrahydroxy-butyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 207454-76-0 Toluene-4-sulfonic acid (4S,5R)-2,2-dimethyl-5-((3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-3a-yl)-[1,3]dioxolan-4-ylmethyl ester 
• 207454-77-1 (3aS,5aR,8aR,8bS)-3a-((4R,5S)-5-Azidomethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran 
• 207454-78-2 (1R,2S,3R)-1-((2R,3S,4S)-3,4-Dihydroxy-pyrrolidin-2-yl)-butane-1,2,3,4-tetraol 
• 177421-51-1 [(4S,5R)-2,2-Dimethyl-5-((3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-3a-yl)-[1,3]dioxolan-4-yl]-methanol 
• 501-53-1 benzyl chloroformate 

Relevant academic research and scientific papers

A new and highly stereoselective synthesis of polyhydroxyindolizidines from 4-octulose derivatives

(1S,2S,6R,7R,8R,8aR)-1,2,6,7,8-Pentahydroxyindolizidine 12 and (1R,6R,7R,8R,8aR)-1,6,7,8-tetrahydroxy-indolizidine (1,6- diepicastanospermine, 24) have been stereoselectively synthesized from the important key intermediates 1,4-dideoxy-1,4-imino-D-erythro-L-altro-octitol 7 and 1,2,4-trideoxy-1,4-imino-D-glycero-D-talo-octitol 20 in three steps. Compounds 7 and 20 were readily obtained from 2,3:4,5:6,7-tri-O- isopropylidene-β-D-glycero-D-galacto-oct-4-ulo-4,8-pyranose 1 and 2-deoxy- 4,5:6,7-di-O-isopropylidene-β-D-manno-oct-4-ulo-4,8 pyranose 13 in four steps, respectively.