207461-31-2Relevant academic research and scientific papers
Structure-activity relationships of a series of 1-substituted-4-methylbenzimidazole neuropeptide Y-1 receptor antagonists
Zimmerman, Dennis M.,Cantrell, Buddy E.,Smith, Edward C.R.,Nixon, James A.,Bruns, Robert F.,Gitter, Bruce,Hipskind, Philip A.,Ornstein, Paul L.,Zarrinmayeh, Hamideh,Britton, Thomas C.,Schober, Douglas A.,Gehlert, Donald R.
, p. 473 - 476 (1998)
The characterization of a novel series of NPY-1 receptor antagonists derived from the 4-methylbenzimidazole 4 is described. Appropriate substitution on the piperidyl nitrogen of 4 led to systematic increases in Y-1 receptor affinity, to approximately 50-fold, and to the discovery of the importance of a second basic substituent.
