207461-32-3

Upstream product

• 193626-34-5 1-(3-(4-(N-BOC-piperidyl))propyl)-2-(4-chlorophenoxymethyl)-4-methylbenzimidazole 
• 193626-88-9 1-(3-(4-piperidyl)propyl)-2-(4-chlorophenoxymethyl)-4-methylbenzimidazole 
• 193629-32-2 2-(4-chlorophenoxymethyl)-4-methylbenzimidazole 
• 164149-27-3 tert-butyl 4-(3-bromopropyl)piperidine-1-carboxylate 
• 207461-30-1 (4-{3-[2-(4-Chloro-phenoxymethyl)-4-methyl-benzoimidazol-1-yl]-propyl}-piperidin-1-yl)-acetic acid ethyl ester 

Downstream Products

• 207461-36-7 2-(4-{3-[2-(4-Chloro-phenoxymethyl)-4-methyl-benzoimidazol-1-yl]-propyl}-piperidin-1-yl)-1-piperidin-1-yl-ethanone 

Relevant academic research and scientific papers

Structure-activity relationships of a series of 1-substituted-4-methylbenzimidazole neuropeptide Y-1 receptor antagonists

The characterization of a novel series of NPY-1 receptor antagonists derived from the 4-methylbenzimidazole 4 is described. Appropriate substitution on the piperidyl nitrogen of 4 led to systematic increases in Y-1 receptor affinity, to approximately 50-fold, and to the discovery of the importance of a second basic substituent.