2076-70-2

Basic information

• Product Name: 2-(p-Methylthiophenyl)imidazo(1,2-a)pyridine
• Synonyms: 2-(p-Methylthiophenyl)imidazo(1,2-a)pyridine
• CAS NO: 2076-70-2
• Molecular Formula: C₁₄H₁₂N₂S
• Molecular Weight: 240.32348
• Mol File: 2076-70-2.mol
• Article Data: 13

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.19g/cm³
• Refractive Index: 1.655
• CAS DataBase Reference: 2-(p-Methylthiophenyl)imidazo(1,2-a)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(p-Methylthiophenyl)imidazo(1,2-a)pyridine(2076-70-2)
• EPA Substance Registry System: 2-(p-Methylthiophenyl)imidazo(1,2-a)pyridine(2076-70-2)

Safety Data

• Hazardous Substances Data: 2076-70-2(Hazardous Substances Data)

Usage

General Description

2-(p-Methylthiophenyl)imidazo(1,2-a)pyridine is a chemical compound that is a derivative of imidazo(1,2-a)pyridine. It is composed of a pyridine ring fused to an imidazole ring, with a p-Methylthiophenyl group attached at the 2-position. 2-(p-Methylthiophenyl)imidazo(1,2-a)pyridine has been studied for its potential use in medicinal and pharmaceutical applications. It has been linked to research on its potential anti-inflammatory, antimicrobial, and anticancer properties. It shows potential as a scaffold for developing new drugs for various diseases and conditions. Further research is ongoing to explore its pharmacological properties and potential therapeutic uses.

InChI:InChI=1/C14H12N2S/c1-17-12-7-5-11(6-8-12)13-10-16-9-3-2-4-14(16)15-13/h2-10H,1H3

Upstream product

• 504-29-0 2-aminopyridine 
• 75-52-5 nitromethane 
• 3446-89-7 4-(Methylthio)benzaldehyde 
• 42445-46-5 2-bromo-1-(4-methylsulfanyl-phenyl)-ethanone 
• 100-68-5 methyl-phenyl-thioether 
• 1778-09-2 4-(Methylthio)acetophenone 
• 710-27-0 1-(4-methylthiophenyl)-2-nitroethene 
• 56041-85-1 4-ethynylthioanisole 

Downstream Products

• 1222-57-7 zolimidine 
• 1609583-35-8 2-(4-(methylthio)phenyl)-3-(phenylthio)imidazo[1,2-a]pyridine 
• 2076-74-6 2-[4-(methylsulfinyl)phenyl]imidazo[1,2-a]pyridine 

Relevant articles and documents

Oxidation Potential-Guided Electrochemical Radical-Radical Cross-Coupling Approaches to 3-Sulfonylated Imidazopyridines and Indolizines

Oxidation potential-guided electrochemical radical-radical cross-coupling reactions between N-heteroarenes and sodium sulfinates have been established. Thus, simple cyclic voltammetry measurement of substrates predicts the likelihood of successful radical-radical coupling reactions, allowing the simple and direct synthetic access to 3-sulfonylated imidazopyridines and indolizines. The developed electrochemical radical-radical cross-coupling reactions to sulfonylated N-heteroarenes boast the green synthetic nature of the reactions that are oxidant- and metal-free.

CuCl2-catalyzed N[sbnd]O bond cleavage of oxime esters: Approach to imidazoheterocycles and furo[3,2-c]chromenyl fused imidazoles

An articulate approach to a diverse set of imidazoheterocycles in good to high yields via a copper-catalyzed aza-annulation of several oxime esters with a group of 2-amino-azaarenes was developed. The above cyclization reaction probably proceeds via a single electron transfer process which embodies a new technique for creating two new C[sbnd]N bonds for imidazole ring synthesis. Gratifyingly, the implementation of this chemistry could be further stretched to the synthesis of a novel class of fused imidazoles bearing a furo[3,2-c]chromene moiety via a sequential C[sbnd]N bond formation, followed by C(sp2)-H functionalization/5-endo-dig-oxacyclization (C[sbnd]C and C[sbnd]O bonds) of in situ produced fused imidazoles with cyclic enynones in the presence of copper(II) as a π-electrophilic Lewis acid catalyst.

Electrochemically initiated intermolecular C-N formation/cyclization of ketones with 2-aminopyridines: An efficient method for the synthesis of imidazo[1,2-: A] pyridines

Electrochemical intermolecular C-N formation/cyclization of ketones with 2-aminopyridines using catalytic hydriodic acid as the redox mediator was developed, providing imidazo[1,2-a]pyridines under more environmentally benign conditions. The reaction proceeds in a simple undivided cell, using low toxic ethanol as the solvent, without external oxidants, and exhibits high atom economy. A variety of ketones including acetophenones, unsatruated and alkyl ketones are amenable to this reaction, affording the corresponding products in moderate to excellent yields. A three-component tandem reaction realizing C-N, C-S/C-Se bond formation can also be achieved under standard conditions.