207607-26-9Relevant academic research and scientific papers
New ruthenium-based protocol for cleavage of terminal olefins to primary alcohols: Improved synthesis of a bicyclic nucleoside
Sharma, Pawan K.,Nielsen, Poul
, p. 5742 - 5745 (2007/10/03)
A new protocol for the oxidative cleavage of terminal alkenes to give exclusively primary alcohols in high yields is introduced. The protocol is based on RuO4-mediated dihydroxylation, NaIO4-mediated diol cleavage, and NaBH4-mediated reduction, but the introduction of a reducing step before the diol cleavage removes the formation of byproducts and improves the yield significantly. The new protocol has been developed and used for the improved preparation of a [3.2.0]bicycloarabinonucleoside with important potential in antisense and antigene technology.
A novel class of oligonucleotide analogues containing 2′-O,3′-C-linked [3.2.0]bicycloarabinonucleoside monomers: Synthesis, thermal affinity studies, and molecular modeling
Christensen, Nanna K.,Petersen, Michael,Nielsen, Poul,Jacobsen, Jens P.,Olsen, Carl Erik,Wengel, Jesper
, p. 5458 - 5463 (2007/10/03)
Oligonucleotide analogues containing a novel 2′-O,3′-C-linked [3.2.0]bicyclonucleoside have been efficiently synthesized. Enhanced thermal stabilities of duplexes toward both RNA and DNA are reported for a 14-mer oligothymidylate containing 13 modificatio
