207610-55-7

Usage

Uses

Used in Pharmaceutical Applications:
[2,2’-bipyridine]-6-carboxamide is utilized as a key component in the synthesis of coordination complexes and metal-organic frameworks, which are essential in the pharmaceutical industry. Its unique structure allows for the creation of new materials with potential applications in drug development and delivery systems.
Used in Catalyst Development:
In the field of catalysis, [2,2’-bipyridine]-6-carboxamide serves as a vital building block for the development of new catalysts. Its presence in these catalysts can enhance their efficiency and selectivity in various chemical reactions, contributing to advancements in chemical processes and industrial applications.
Used in Optoelectronic Device Manufacturing:
[2,2’-bipyridine]-6-carboxamide is also used as a constituent in the production of optoelectronic devices. Its unique structure and properties make it suitable for the development of materials with enhanced performance in areas such as light emission, detection, and energy conversion, which are crucial for the advancement of optoelectronic technology.
Used in Chemical Research:
[2,2’-bipyridine]-6-carboxamide is employed as a subject of interest in chemical research. Its distinctive structure and potential applications across various industries make it an attractive candidate for further investigation, potentially leading to the discovery of new materials and processes with significant implications in multiple fields.

Upstream product

• 4392-85-2 2,2'-bipyridyl-6-carbonitrile 
• 10495-73-5 2-bromo-6-(pyridin-2-yl)pyridine 
• 15226-74-1 dicobalt octacarbonyl 
• 33421-43-1 2,2'-bipyridyl N-oxide 
• 366-18-7 [2,2]bipyridinyl 

Relevant academic research and scientific papers

Donor atom set and spin state of iron(II). Bis(ligand)iron(II) and bis(ligand)nickel(II) complexes of 2,2′-bipyridine-6-carbothioamide and 2,2′-bipyridine-6-carboxamide

2,2′-Bipyridine-6-carbothioamide (bpytm) and 2,2′-bipyridine-6-carboxamide (bpyam) are NNS and NNO donors, respectively, in their cationic bis(ligand)iron(II) and bis(ligand)nickel(II) complexes. The former ligand provides the stronger field and salts of [Fe(bpytm)2]2+ have a singlet ground state, while those of [Fe(bpyam)2]2+ have a quintet ground state. The magnetism and the electronic and Moessbauer spectra of salts of these cations have been measured. The low-temperature Moessbauer spectra of iron(II) complex salts of the carboxamide indicate, for the perchlorate and triflate salts, but not for the fluoroborate salt, a partial transition to singlet-state species. The mode of coordination of the ligands is indicated by infrared spectral data and has been confirmed by determination of the structures of [Ni(bpytm)2] Cl2.4H2O, [Ni(bpyam)2] [BF4]2.H2O and [Fe(bpyam)2] [BF4]2. In addition, the structures of the free ligands have been determined. Hydrogen bonding is present in the free ligands and their complexes. 2,2′-Bipyridine-6-carbothioamide: monoclinic, space group p21/c, a 8.265(3), b 11.175(2), c 11.114(4) A, β 94.47(2)°, Z 4. 2,2′-Bipyridine-6-carboxamide: monoclinic, space group P21/c, a 13.581(2), b 9.926(1), c 16.824(3) A, β 116.481(7)°, Z 8. [Ni(bpytm)2] Cl2.4H2O: triclinic, space group P1, a 9.291(5), b 12.426(7), c 13.425(7) A, α 113.54(3), β 95.63(3)°, γ 94.43(3)°, Z 2. [Ni(bpyam)2][BF4]2.H2O: triclinic, space group P1, a 10.663(5), b 10.861(6), c 12.799(6) A, α 68.70(4), β 77.84(4), γ 78.47(4)°, Z 2. [Fe(bpyam)2] [BF4]2: orthorhombic, space group P bcn, a 12.317(6), b 12.609(4), c 16.644(8) A, Z 4.

Synthesis of primary amides by aminocarbonylation of aryl/hetero halides using non-gaseous NH3 and CO sources

Abstract A practically simple method for the synthesis of primary amides via the palladium-catalysed aminocarbonylation of aromatic halides by using solid sources of gaseous ammonia and carbon monoxide is described. The system tolerated a wide variety of hindered and functionalized aryl/hetero halides and afforded good to excellent yields (69-94%) of the amide. Pharmacologically active Exalamide and Pyrazinecarboxamide were synthesised in high yields to demonstrate the effectiveness of this method.

Regioselective functionalization of 2,2′-bipyridine and transformations into unsymmetric ligands for coordination chemistry

Novel synthetic strategies for a series of unsymmetrically substituted 2,2′-bipyridines have been developed. These bipyridines have found use in some novel homoleptic and heteroleptic ruthenium(II) complexes. Two methods for regiochemical control of nucleophilic addition to bpy have been explored: (i) mono N-oxidation followed by cyanation and subsequent hydrolysis gave 6-carboxy-2,2′-bipyridine (4); (ii) mono N-methylation followed by the conversion into 6-bromo-2,2′-bipyridine (12) and subsequent nucleophilic addition of lithioacetonitrile followed by hydrolysis of 6-cyanomethyl-2,2′-bipyridine (8) gave the homologous 2,2′-bipyridine-6-acetic acid (9). An established method of regioselective mono-ring alkylation of bpy using methyllithium yielded 6-methyl-2,2′-bipyridine (14), and the generation of the anion of 14 and subsequent addition to a chloromethyl oxazoline was applied to synthesize a second homologue, methyl 2,2′-bipyridine-6-propanoate (16). Structural determinations using 1H, 13C and 2D NMR spectroscopy permitted complete assignments of all signals in the 1H NMR spectra. Acta Chemica Scandinavica 1998.