207612-89-3Relevant academic research and scientific papers
Branched peptide linkers
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, (2008/06/13)
Conjugates containing a targeting ligand, such as an antibody, a therapeutically active drug and a branched peptide linker. The branched peptide linker contains two or more amino acid moieties that provide an enzyme cleavage site. The number of drugs capable of being bonded to the branched linkers varies by a factor of two for each generation of branching.
Doxorubicin immunoconjugates containing bivalent, lysosomally-Cleavable dipeptide linkages
Dubowchik, Gene M,Radia, Shilpa,Mastalerz, Harold,Walker, Michael A.,Firestone, Raymond A.,Dalton King, H.,Hofstead, Sandra J.,Willner, David,Lasch, Shirley J.,Trail, Pamela A.
, p. 1529 - 1532 (2007/10/03)
Bivalent doxorubicin (DOX)-dipeptides (16a-c) were prepared and conjugated to the monoclonal antibody BR96. The dipeptides are cleaved by lysosomal proteases following internalization of the resulting immunoconjugates. Conjugate 18b demonstrated antigen-s
Facile synthesis of maleimide bifunctional linkers
King, H.Dalton,Dubowchik, Gene M,Walker, Michael A
, p. 1987 - 1990 (2007/10/03)
The synthesis of maleimide containing derivatives capable of serving as linkers for the conjugation of proteins is described. These compounds differ from previously reported linkers by having multiple sites available for drug attachment. Compounds 3a, 3b,
