207670-20-0Relevant academic research and scientific papers
The design, synthesis and physical chemical properties of novel human vasopressin V2-receptor antagonists optimized for parenteral delivery
Ashwell,Bagli,Caggiano,Chan,Molinari,Palka,Park,Rogers,Sherman,Trybulski,Williams
, p. 783 - 786 (2000)
Ionizable groups were introduced onto the 10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine scaffold of the vasopressin V2-antagonist WAY-VPA-985 in the search for molecules optimized for parenteral formulation. The synthesis and structure-activity relationships (SAR) are presented together with solubility data in a model parenteral system. The amine, WAY-140288 (4f), was chosen for further development. (C) 2000 Elsevier Science Ltd. All rights reserved.
