207671-42-9 Usage
Description
PYRIDINE-2,4-DICARBOXYLIC ACID MONOHYDRATE, also known as 2,4-Pyridinedicarboxylic Acid (2,4-PDCA), is a compound that structurally resembles 2-oxoglutarate (2-OG) and chelates zinc, thereby influencing a variety of enzymes. As a 2-OG mimic, it inhibits the activity of 2-OG oxygenases, which include certain lysine demethylases and a range of hydroxylases (e.g., prolyl, collagen, lysyl). 2,4-PDCA is effective at low micromolar concentrations in inhibiting several Jumonji domain-containing lysine demethylases. Additionally, it modulates the turnover of hypoxia-inducible factors, collagen synthesis, and plant cell wall formation through its effects on hydroxylases, including prolyl hydroxylase 1 (IC50 = 1.5 μM). Furthermore, it can inhibit zinc-dependent enzymes, such as metallo-β-lactamase, and is translocated by organic anion transporters.
Uses
Used in Pharmaceutical Industry:
PYRIDINE-2,4-DICARBOXYLIC ACID MONOHYDRATE is used as an inhibitor for targeting specific enzymes, such as Jumonji domain-containing lysine demethylases, due to its ability to inhibit these enzymes at low micromolar concentrations.
Used in Research Applications:
PYRIDINE-2,4-DICARBOXYLIC ACID MONOHYDRATE is used as a research tool for studying the effects of 2-oxoglutarate oxygenases and their role in various biological processes, including hypoxia-inducible factor turnover, collagen synthesis, and plant cell wall formation.
Used in Enzyme Inhibition Studies:
PYRIDINE-2,4-DICARBOXYLIC ACID MONOHYDRATE is used as an inhibitor of zinc-dependent enzymes, like metallo-β-lactamase, to investigate the role of these enzymes in different biological systems.
Used in Drug Development:
PYRIDINE-2,4-DICARBOXYLIC ACID MONOHYDRATE is used as a lead compound in the development of new drugs targeting various enzymes and pathways, potentially leading to therapeutic applications in treating diseases associated with the dysregulation of these targets.
Check Digit Verification of cas no
The CAS Registry Mumber 207671-42-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,7,6,7 and 1 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 207671-42:
(8*2)+(7*0)+(6*7)+(5*6)+(4*7)+(3*1)+(2*4)+(1*2)=129
129 % 10 = 9
So 207671-42-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H5NO4.H2O/c9-6(10)4-1-2-8-5(3-4)7(11)12;/h1-3H,(H,9,10)(H,11,12);1H2