207680-02-2Relevant academic research and scientific papers
Lanthanide trifluoromethanesulfonate catalysed selective acylation of 10-deacetylbaccatin III
Damen, Eric W. P.,Braamer, Lesly,Scheeren, Hans W.
, p. 6081 - 6082 (1998)
The selective C-10 acylation of 10-deacetylbaccatin III to baccatin III and derivatives is very efficiently catalysed by lanthanide trifluoromethanesulfonates. Baccatin III, now readily available through this procedure, is an important precursor for an economically viable semisynthesis of paclitaxel and its derivatives.
Organocatalytic site-selective acylation of 10-deacetylbaccatin III
Yanagi, Masanori,Ninomiya, Ryo,Ueda, Yoshihiro,Furuta, Takumi,Yamada, Takeshi,Sunazuka, Toshiaki,Kawabata, Takeo
, p. 907 - 912 (2016/07/14)
Organocatalytic site-selective diversification of 10-deacetylbaccatin III, a key natural product for the semisynthesis of taxol, has been achieved. Various acyl groups were selectively introduced into the C(10)-OH of 10-deacetylbaccatin III. The C(10)-OH selective acylation was also applied to acylative site-selective dimerization of 10-deacetylbaccatin III to provide the structurally defined dimer.
Synthesis and biological evaluation of C-3′NH/C-10 and C-2/C-10 modified paclitaxel analogues
Baloglu, Erkan,Hoch, Jeannine M.,Chatterjee, Sabarni K.,Ravindra, Rudravajhala,Bane, Susan,Kingston, David G. I.
, p. 1557 - 1568 (2007/10/03)
Concurrent modifications on the C-3′NH/C-10, and C-2/C-10 positions on paclitaxel were carried out as a way of investigating possible synergistic effects. The biological activities of these analogues were evaluated in both a microtubule assembly assay and
