20771-70-4

Upstream product

• 104-94-9 4-methoxy-aniline 
• 123-54-6 acetylacetone 

Downstream Products

• 100291-02-9 MoO₂Cl₂[CH₃C(O)CHC(NHC₆H₄OCH₃)CH₃]2 
• 1151785-99-7 5-acetyl-4-hydroxy-1-(4-methoxyphenyl)-6-methyl-3-phenyl-2(1H)-pyridinone 
• 352548-78-8 3-acetyl-5-hydroxy-2-methyl-6,8-diphenylfuro[2,3-e]indazole 
• 171506-55-1 5-Acetyl-1-(4-methoxy-phenyl)-6-methyl-3,4-dihydro-1H-pyridin-2-one 
• 54196-37-1 (Z)-4-(4-Methoxy-phenylamino)-pent-3-ene-2-thione 

Relevant academic research and scientific papers

Immobilization and DFT studies of Tin chloride on UiO-66 metal–organic frameworks as active catalyst for enamination of acetylacetone

An efficient synthetic method for the preparation of β-enaminones catalyzed by immobilization of SnCl2 on Zr-metal–organic frameworks (UiO-66 MOF) and designated as SnUiO66 is described. Also the prepared catalyst was characterized by Fourier t

Redox Non-Innocence and Isomer-Specific Oxidative Functionalization of Ruthenium-Coordinated β-Ketoiminate

This article deals with isomeric ruthenium complexes [RuIII(LR)2(acac)] (S=1/2) involving unsymmetric β-ketoiminates (AcNac) (LR=R-AcNac, R=H (1), Cl (2), OMe (3); acac=acetylacetonate) [R=para-substituents (H,

β-Enaminones over recyclable nano-CoFe2O4: a highly efficient solvent-free green protocol

Abstract: β-Enaminone and its derivatives have emerged among the finest bioactive intermediates. High yields of several β-enaminones (86–97%) are achieved through treatment of substituted aromatic and aliphatic amines with cyclic/acyclic 1,3-diketones, over the magnetically separable cobalt ferrite nanoparticles (CoFe2O4 NPs). The latter was prepared upon co-precipitation. Its purity, fine crystallinity, elemental distributions, morphology, magnetic features, and thermal stability were confirmed by Fourier transform infrared, X-ray diffraction, energy dispersive X-ray spectrometry, scanning electron microscopy, vibrating sample magnetometry, and thermal gravimetric analysis analyses. Thus, CoFe2O4 NPs acted as an excellent green heterogeneous nanocatalyst for synthesis of β-enaminones and gave good recyclability, while showing insignificant loss of their activity. Graphical Abstract: [Figure not available: see fulltext.].

Nano-SiO2 catalyzed synthesis of β-enaminones under solvent free conditions

Nano-SiO2 efficiently catalyzed the synthesis of β-enaminones using direct condensation of various (cyclic and acyclic) β-diketones with aromatic and aliphatic amines under solvent-free conditions. This eco-friendly catalyst can be recovered and reused without significant loss of activity. This methodology provides a simple synthetic route to enaminones in excellent yields at room temperature. Graphical abstract: [Figure not available: see fulltext.]

Bimetallic Ag-Cu alloy nanoparticles as a highly active catalyst for the enamination of 1,3-dicarbonyl compounds

Bimetallic nanoparticles, particularly those based on copper, have recently attracted a great deal of attention for the development of low cost and highly active catalysts due to the synergistic interaction between individual metal components. In this work, bimetallic Ag-Cu alloy nanoparticles were explored as a highly active and reusable catalyst for the enamination of 1,3-dicarbonyls using diverse amines. The nanocatalysts were intensively characterized by ultraviolet-visible (UV-Vis) spectroscopy, X-ray diffraction (XRD), high-resolution transmission electron microscopy-energy-dispersive spectroscopy (HRTEM-EDS) and valence band and core level X-ray photoelectron spectroscopy (XPS) to study the effect of the bimetallic structure and composition. In comparison to monometallic Ag and Cu nanoparticles, the alloyed Ag-Cu nanoparticles showed a high catalytic performance and the resultant catalytic activity was dependant on the Ag to Cu ratio. This enhanced catalytic activity should be related to the electronic interaction between Ag and Cu nanoparticles formed due to the intimate contact between them. Our study may serve as a foundation for designing efficient alloyed nanocatalysts for fine chemical synthesis via enamination reactions.

FeCl3-Catalyzed Combinatorial Synthesis of Functionalized Spiro[Indolo-3,10′-indeno [1,2- b ]quinolin]-trione Derivatives

An efficient, inexpensive, environmentally friendly and high yield one-pot route to new spiro[indolo-3,10′-indeno [1,2-b]quinolin]-trione derivatives has been developed, involving three-component reaction of enaminones, N-substituted isatins and Indane-1,3-dione catalyzed by FeCl3. The approach to this spiro-heterocycle is noteworthy because it results in the formation of three new σ (two C-C and one C-N) bonds in a single operation, leading to the construction of novel spiro skeleton. This method works on a large scale in excellent yields.

Nano fibrous silica sulphuric acid as an efficient catalyst for the synthesis of β-enaminone

Synthesis of KCC-1 silica sulphuric acid as a new catalyst has been reported. The catalyst was characterized using XRD, SEM, TEM, BET, FT-IR, TGA-DTA, and EDX analysis. The catalytic activity was evaluated for the synthesis of enaminones under solvent-free conditions. The catalyst was easily recovered and reused up to seven cycles with slight loss of activity. The attractive features of this protocol are low amount of catalyst loading, short reaction time, mild reaction conditions, good to excellent yield of the products, easy handling of the catalyst and simple operational procedure. Graphical Abstract: [InlineMediaObject not available: see fulltext.]A highly efficient Sulphated nanosilica sulphuric acid has been synthesized and applied for the synthesis of enaminones. This catalytic protocol is better for the synthesis of enaminone than previously reported procedures in terms of catalyst loading, reaction condition, reaction time and yields of the products.

Aluminum methyl and isopropoxide complexes with ketiminate ligands: Synthesis, structural characterization and ring-opening polymerization of cyclic esters

Mono(ketiminate) aluminum dimethyl complexes 1a-5a and bis(ketiminate) aluminum methyl complex 2b were synthesized via the reactions of AlMe 3 with various N-aryl substituted ketimine compounds in a 1:1 or 1:2 molar ratio, respectively. The rea

Facile synthesis of substituted pyrrole-fused isocoumarins from ninhydrin

A simple and efficient procedure has been developed for the synthesis of substituted pyrrole-fused isocoumarins from easily available ninhydrin. The cyclic hemiaminal dihydroxy-indenopyrroles, the adducts of ninhydrin with enamines of acetylacetone, give pyrrole-fused isocoumarins upon heating in acidic medium. The process constitutes an interesting acid-catalyzed rearrangement to eight-membered lactams followed by intramolecular cyclization involving the amino and keto groups.

Solvent-free synthesis of β-enamino compounds promoted by Ferric(III) ammonium nitrate

A variety of β-enamino esters and β-enaminones can be synthesized by the reaction of 1,3-dicarbonyl compounds and various primary amines in the presence of catalytic amount of ferric(III) ammonium nitrate at room temperature. This method is simple, requires short reaction times, high yield and the reaction proceeds under solvent-free conditions.