20772-07-0

Basic information

• Product Name: 2-Propanone, 1-bromo-3-(4-nitrophenyl)-
• Synonyms: Brommethyl-p-nitrobenzyl-keton;1-bromo-3-p-nitrophenylpropan-2-one
• CAS NO: 20772-07-0
• Molecular Formula: C9H8BrNO3
• Molecular Weight: 258.071
• Mol File: 20772-07-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Propanone, 1-bromo-3-(4-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propanone, 1-bromo-3-(4-nitrophenyl)-(20772-07-0)
• EPA Substance Registry System: 2-Propanone, 1-bromo-3-(4-nitrophenyl)-(20772-07-0)

Safety Data

• Hazardous Substances Data: 20772-07-0(Hazardous Substances Data)

Upstream product

• 5332-96-7 1-(4-nitrophenyl)propan-2-one 
• 186581-53-3 diazomethane 
• 104-03-0 4-nitrobenzeneacetic acid 

Downstream Products

• 689251-49-8 2-ethyl-4-(4-nitrobenzyl)-1,3-thiazole 
• 897934-60-0 4-(4-nitrobenzyl)-1,3-thiazol-2-amine hydrobromide 
• 91397-47-6 N-[4-(4-nitrobenzyl)-1,3-thiazol-2-yl]acetamide 
• 1426055-77-7 N-[4-(4-aminobenzyl)-1,3-thiazol-2-yl]acetamide 
• 1426121-88-1 N-[4-(4-carbamimidamidobenzyl)-1,3-thiazol-2-yl]acetamide 
• 79908-79-5 1-(4-Methylthio-2-oxoazetidin-1-yl)-3-(p-nitrophenyl)-propan-2-one 

Relevant articles and documents

Synthesis and SAR study of new thiazole derivatives as vascular adhesion protein-1 (VAP-1) inhibitors for the treatment of diabetic macular edema

Vascular adhesion protein-1 (VAP-1), an amine oxidase that is also known as a semicarbazide-sensitive amine oxidase (SSAO), is present in particularly high levels in human plasma, and is considered a potential therapeutic target for various inflammatory diseases, including diabetes complications such as macular edema. In our VAP-1 inhibitor program, structural modifications following high-throughput screening (HTS) of our compound library resulted in the discovery that thiazole derivative 10, which includes a guanidine group, shows potent human VAP-1 inhibitory activity (IC50 of 230 nM; rat IC 50 of 14 nM). Moreover, compound 10 exhibited significant inhibitory effects on ocular permeability in STZ-induced diabetic rats.

Aminobenzyl and aminocyclohexylmethyl imidazoles

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