20772-84-3Relevant academic research and scientific papers
The effect of intramolecular hydrogen bond on the ultraviolet absorption of bi-aryl Schiff bases
Cao, Chao-Tun,Li, Luyao,Cao, Chenzhong,Liu, Junlan
, (2020/12/01)
Two kinds of Schiff bases, 85 samples of N-(benzylidene)-anilines (ZBAY) and 83 samples of N-(phenyl-ethylene)-anilines (ZAPEY), were used as model compounds, in which the ZBAY contains 13 compounds with 2-OH and the ZAPEY contains 35 compounds with 2-OH
Design, synthesis, and biological activity of Schiff bases bearing salicyl and 7-hydroxycoumarinyl moieties
Hejchman, El?bieta,Kruszewska, Hanna,Maciejewska, Dorota,Sowirka-Taciak, Barbara,Tomczyk, Magdalena,Sztokfisz-Ignasiak, Alicja,Jankowski, Jan,M?ynarczuk-Bia?y, Izabela
, p. 255 - 266 (2019/01/16)
Abstract: 18 (11 novel) Schiff bases, derivatives of salicylaldehyde, 2-hydroxyacetophenone, and 6-acetyl-, 8-acetyl-, and 8-formyl-7-hydroxy-4-methylcoumarin were synthesized and characterized by their spectral studies. 6-Acetyl-7-hydroxy-4-methylcoumarin was prepared by novel method under microwave assistance. These Schiff bases were evaluated for antibacterial activities against 12 bacterial and six fungi strains in vitro. N-(3,5-Dichloro-2-hydroxybenzylidene)-4-aminobenzenesulfonic acid sodium salt proved to be the most active against Staphylococcus aureus and MRSA strains (MIC 0.0194?μmol/cm3). The substitution pattern, two chlorine atoms in the salicylidene ring and the SO3Na group, is probably the most beneficial for the activity against Gram-(+) bacteria strains. All Schiff bases were evaluated for cancer efficacy against CFPAC-1 and HeLa cell cultures originating from human pancreas cancer or human cervical cancer. Schiff bases derived from salicylaldehyde are highly effective in pancreas and cervical cancer cells; however, they demonstrate also substantial toxicity towards NIH3T3 cells. Derivatives of coumarin contain three highly selective compounds: 7-hydroxy-8-[(4-methoxyphenylimino)methyl]-4-methyl-2H-chromen-2-one, N-[(7-hydroxy-4-methyl-2-oxo-2H-chromen-8-yl)methylene]-4-aminobenzenesulfonic acid sodium salt, and 7-hydroxy-8-[1-(4-hydroxyphenylimino)ethyl]-4-methyl-2H-chromen-2-one suggesting more promising potential of the second group of substances.
New Route for the Preparation of 2H-3-Aryl-3,4-dihydro-1,3-benzoxazines and 2H-3-Aryl-3,4-dihydro-4-methyl-1,3-benzoxazines
Joglekar, S. J.,Samant, S. D.
, p. 110 - 111 (2007/10/02)
2-Hydroxybenzaldehyde (1) and 1-(2-hydroxyphenyl)ethanone (2) on reaction with different primary aromatic amines gave 2-(arylimino)methylphenols (3) and 2-phenols (4), respectively. 3 and 4 on reduction with sodium borohydride gave 2-(arylamino)methylphenols (5) and 2-phenols (6), which underwent cyclisation with formaldehyde to form 2H-3-aryl-3,4-dihydro-1,3-benzoxazines (7) and 2H-3-aryl-3,4-dihydro-4-methyl-1,3-benzoxazines (8), respectively.
