207789-85-3

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 207789-84-2 (3R,4S,5R,7S)-3,4-Dihydroxy-7-(4-methoxy-benzyloxy)-5-methyl-octan-2-one 
• 824-94-2 p-methoxybenzyl chloride 
• 207789-81-9 Toluene-4-sulfonic acid (1S,3S)-3-(4-methoxy-benzyloxy)-1-methyl-butyl ester 
• 72345-23-4 (2S,4S)-pentane-2,4-diol 
• 207789-83-1 (E)-(5R,7S)-7-(4-Methoxy-benzyloxy)-5-methyl-oct-3-en-2-one 
• 207789-82-0 (2R,4S)-4-(4-Methoxy-benzyloxy)-2-methyl-pentanenitrile 
• 274693-86-6 (2R,4S)-4-(4-Methoxy-benzyloxy)-2-methyl-pentanal 

Downstream Products

• 309241-55-2 (E)-(3R,5S,8R,9S,10R,12S)-3,8,9-Tris-(tert-butyl-dimethyl-silanyloxy)-1-iodo-12-(4-methoxy-benzyloxy)-2,3,10-trimethyl-5-triethylsilanyloxy-tridec-1-en-7-one 
• 309241-36-9 (E)-(3R,5S,8R,9S,10R,12S)-3,8,9-Tris-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-1-iodo-12-(4-methoxy-benzyloxy)-2,3,10-trimethyl-tridec-1-en-7-one 

Relevant academic research and scientific papers

Total syntheses of amphidinolides B, G, and H

Not one, not two, but three: Total syntheses of amphidinolides B, G, and H, which exhibit strong, nanogram-scale cytotoxicity against various tumor cell lines, have been executed. The synthetic strategy relied on implementation of a diene construction protocol and a diastereoselective aldol process. The 26- and 27-membered macrocyclic lactone rings were efficiently constructed by using ring-closing metathesis (RCM). Copyright

Studies Towards a Total Synthesis of Amphidinolide B. Stereocontrolled Synthesis of the C14-C26 Polyol Fragment

A practical synthesis of the C14-C26 polyol unit 2 in amphidinolides B1 and B2, 1, is described which involves elaboration of the chiral unsaturated aldehyde 4 and the chiral ketone 5, followed by crossed-aldolisation of 4 and 5 in the presence of LiHMDS at -78 deg C, as key steps.