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Kinetics and Mechanism of Reactions of Amides with Formaldehyde
Nair, B. Raveendran,Francis, Joseph
, p. 159 - 161 (2007/10/02)
Kinetics of the reactions of substituted ureas like methylurea, phenylurea, acetamide and benzamide with formaldehyde have been studied, using a TLC method developed for the purpose.The increased reactivity of methylurea towards formaldehyde, as compared to urea, is due to the electron-releasing nature of the methyl group.The reduced reactivity of phenylurea is due to the electron-withdrawing nature of the phenyl group.The reduced reactivity observed in the case of acetamide and benzamide is also explained.
