207797-05-5

Basic information

• Product Name: 1-(4-(Trifluoromethyl)phenyl)-1H-pyrazole
• Synonyms: 1-(4-(Trifluoromethyl)phenyl)-1H-pyrazole
• CAS NO: 207797-05-5
• Molecular Formula: C₁₀H₇F₃N₂
• Molecular Weight: 212.18
• Mol File: 207797-05-5.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 240.4 °C at 760 mmHg
• Flash Point: 99.2 °C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 0.0589mmHg at 25°C
• Refractive Index: 1.522
• CAS DataBase Reference: 1-(4-(Trifluoromethyl)phenyl)-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-(Trifluoromethyl)phenyl)-1H-pyrazole(207797-05-5)
• EPA Substance Registry System: 1-(4-(Trifluoromethyl)phenyl)-1H-pyrazole(207797-05-5)

Safety Data

• Hazardous Substances Data: 207797-05-5(Hazardous Substances Data)

Usage

General Description

1-(4-(Trifluoromethyl)phenyl)-1H-pyrazole is a chemical compound with the molecular formula C10H7F3N2. It is an organic compound that belongs to the class of pyrazoles, which are heterocyclic aromatic compounds containing a five-membered ring with two nitrogen atoms. This specific compound contains a trifluoromethyl group and a phenyl group attached to a pyrazole ring. It is used in various applications, including pharmaceuticals, agrochemicals, and materials science. The trifluoromethyl group can influence the chemical and physical properties of the compound, making it potentially valuable in research and development. Additionally, the phenyl group can contribute to the compound's aromaticity and reactivity. Overall, 1-(4-(Trifluoromethyl)phenyl)-1H-pyrazole is a versatile chemical with potential uses in a wide range of industries.

InChI:InChI=1/C10H7F3N2/c11-10(12,13)8-2-4-9(5-3-8)15-7-1-6-14-15/h1-7H

Upstream product

• 288-13-1 NH-pyrazole 
• 402-44-8 4-Fluorobenzotrifluoride 
• 122-31-6 malondialdehyde bis(diethyl acetal) 
• 2923-56-0 4-(trifluoromethyl)phenylhydrazine hydrochloride 
• 455-13-0 4-Iodobenzotrifluoride 
• 98-56-6 4-chlorobenzotrifluoride 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 128796-39-4 4-trifluoromethylphenylboronic acid 

Downstream Products

• 1443331-02-9 C₁₇H₁₇N₃O₂S 
• 1007678-92-3 C₁₇H₁₄F₃N₃O₂S 
• 1379667-34-1 N-[2-(1H-pyrazol-1-yl)phenyl]-4-methylbenzenesulfonamide 
• 1426830-32-1 1-(4-(trifluoromethyl)phenyl)-1H-pyrazole-4-carbaldehyde 
• 1314002-55-5 5-iodo-1-[2-iodo-4-(trifluoromethyl)phenyl]-1H-pyrazole 
• 1260140-73-5 4,5-diphenyl-7-trifluoromethylpyrazolo[1,5-a]quinoline 
• 861162-10-9 2-ethyl-1-{1-[4-(trifluoromethyl)phenyl]-1H-pyrazol-5-yl}butan-1-ol 

Relevant articles and documents

INHIBITOR COMPOUNDS

The disclosure relates to heterocyclic compounds and methods for their preparation. The disclosure provides compounds that may have beneficial therapeutic activity in the treatment of a disease or condition mediated by excessive or otherwise undesirable Des1 and/or fibrotic activity.

Design, synthesis, and evaluation of indeno[2,1-c]pyrazolones for use as inhibitors against hypoxia-inducible factor (HIF)-1 transcriptional activity

HIF-1 is regarded as a promising target for the drugs used in cancer chemotherapy, and creating readily accessible templates for the development of synthetic drug candidates that could inhibit HIF-1 transcriptional activity is an important pursuit. In this study, indeno[2,1-c]pyrazolones were designed as readily available synthetic inhibitors of HIF-1 transcriptional activity. Nine compounds were synthesized in 4–5 steps from commercially available starting materials. In evaluations of the ability to inhibit the hypoxia-induced transcriptional activity of HIF-1, compound 3c showed a higher level compared with that of known inhibitor, YC-1. The compound 3c suppressed HIF-1α protein accumulation without affecting the levels of HIF-1α mRNA.

Tunable Emission Color of Iridium(III) Complexes with Phenylpyrazole Derivatives as the Main Ligands for Organic Light-Emitting Diodes

Seven cyclometalated iridium(III) complexes Ir1-Ir7 based on phenylpyrazole derivatives as main ligands and tetraphenylimidodiphosphinate (tpip) as the ancillary ligand were synthesized and fully characterized. The proligands of 1-[4-(trifluoromethyl)phenyl]-1H-pyrazole (cf3ppz, 2a), substituted phenyl-2H-indazole {2-phenyl-2H-indazole (h-1-pidz, 2b), 2-(4-fluorophenyl)-2H-indazole (f-1-pidz, 2c), and 2-[4-(trifluoromethyl)phenyl]-2H-indazole (cf3-1-pidz, 2d)}, and substituted phenyl-1H-indazole {1-phenyl-1H-indazole (h-7-pidz, 2e), 1-(4-fluorophenyl)-1H-indazole (f-7-pidz, 2f), and 1-[4-(trifluoromethyl)phenyl]-1H-indazole (cf3-7-pidz, 2g)} were prepared with good yields. The emission maxima of all Ir(III) complexes can be tuned from 453 to 576 nm with different photoluminescence quantum yields (10.4-70.9%) by varying the type of substituent on the different main ligand frameworks. The organic light-emitting diodes using Ir(III) complexes as the emitters with blue, bluish-green, and yellow colors exhibit a maximum current efficiency and an external quantum efficiency of 39.2 cd A-1 and 14.8%, respectively.