20783-19-1

Usage

Uses

4-Amino-2-methylpyrimidin-5-ol is used in the diazo coupling reactions of pyrimidines.

Upstream product

• 36591-61-4 4-amino-5-hydroxy-2-methylpyrimidin-6(1H)-one 
• 38953-43-4 4-amino-6-chloro-5-hydroxy-2-methylpyrimidine 

Relevant academic research and scientific papers

Synthesis of 6-oxo-6,7,8,9-tetrahydro-10H-pyrimido-[5,4-b][1,4]benzoxazines and 6-oxo-6,7,8,9-tetrahydropyrimido[4,5-b][1,4]benzodioxanes

Reaction of 5-hydroxy-6-aminopyrimidines with 2-bromohydroresorcinol and bromodimedone in DMF in the presence of sodium hydride gave 6,7,8,9-tetrahydro-10H-pyrimido[5,4-b][1,4]benzoxazines. When 4-chloro-5-hydroxy-6-aminopyrimidine was treated with bromodimedone the principal products were 6,7,8,9-tetrahydropyrimido[4,5-b][1,4]benzodioxanes. The nucleophilic substitution of the chlorine atom in position 4 of the tetrahydropyrimidobenzoxazines by amines, sodium alkanoates, and thiourea has been studied and the corresponding amines and alkoxy- and thio derivatives of this tricyclic system obtained. 1999 Kluwer Academic/Plenum Publishers.

THE SYNTHESIS AND SOME REACTIONS OF CHLOROPYRIMIDINES

Several chloro-hydroxy- and amino- chloropyrimidines have been prepared.The chloro groups have been replaced by hydrogen, mercapto, or hydroxyamino substituents to give useful synthetic intermediates.