207844-87-9Relevant academic research and scientific papers
Toward the antibody-catalyzed chemiluminescence. Design and synthesis of hapten
Sawa, Masaaki,Imaeda, Yasuhiro,Hiratake, Jun,Fujii, Ryota,Umeshita, Ritsuko,Watanabe, Mitsuo,Kondo, Hitoshi,Oda, Jun'ichi
, p. 647 - 652 (2007/10/03)
Hapten 4 was synthesized to generate catalytic antibodies triggering chemiluminescence by catalyzing the decomposition of the 1,2-dioxetane 3. The hapten 4 was so designed as to elicit a negatively charged functional group in the antibody combining site to catalyze the β-elimination of the protecting group in 3 as well as to lock the protecting group into an energetically favorable anti-periplanar conformation.
