20785-90-4

Usage

Chemical class

beta-carboline alkaloids

Derivative

1H-beta-carboline-1-one

Methyl group positions

2 and 9

Potential pharmacological activities

Yes

Neuropharmacological properties

Yes, affecting neurotransmitter systems

Therapeutic applications

Potential use in treating Parkinson's disease and dementia

Ongoing research

In the fields of medicinal chemistry and neuropharmacology.

Upstream product

• 17952-82-8 1,2,3,4-tetrahydronorharman-1-one 
• 74-88-4 methyl iodide 
• 5956-86-5 tryptamine-2-carboxylic acid 
• 603-76-9 1-methylindole 
• 37637-29-9 N-methyl-2-(1-methyl-1H-indol-3-yl)ethan-1-amine 
• 201230-82-2 carbon monoxide 
• 39232-92-3 N-methyl-N-phenylhydrazine hydrochloride 
• 59157-01-6 3-<(N,N-dimethylamino)methylene>-1-methyl-2-pyrrolidinone 

Downstream Products

• 37637-29-9 N-methyl-2-(1-methyl-1H-indol-3-yl)ethan-1-amine 
• 75142-75-5 2-p-chlorophenylsulphonylimino-1,1'-dimethyl-2'-oxoindoline-3-spiro-3'-pyrrolidine 

Relevant academic research and scientific papers

Pd/Cu Cocatalyzed Oxidative Tandem C-H Aminocarbonylation and Dehydrogenation of Tryptamines: Synthesis of Carbolinones

The Pd/Cu cocatalyzed oxidative tandem C-H aminocarbonylation and dehydrogenation was developed, affording carbolinones with molecular oxygen as the terminal oxidant. Natural product strychnocarpine and its derivatives were prepared conveniently using this strategy.

Method for synthesizing tetrahydro beta-carboline-1-one compound through palladium catalysis

The invention discloses a method for synthesizing a tetrahydro beta-carboline-1-one compound through palladium catalysis. According to the method, carbonic oxide is used as a carbonyl source; the carbonic oxide and a tryptamine type compound react at ordinary pressure for efficiently preparing the tetrahydro beta-carboline-1-one compound. The method has the advantages that the tetrahydro beta-carboline-1-one compound with great application prospects is effectively prepared by using the carbonic oxide at the ordinary pressure as the carbonyl source and using bivalent metal palladium as a catalyst. From the angle of production and economy, through being compared with high-pressure reaction, the method has the advantages that the reaction cost is greatly reduced through carbonic oxide gas at normal temperature, and the reaction operability is improved.

The Reactions of Some Tetrahydro-β-Carbolines, of Hexahydroazepinoindoles, and of Tetrahydrocarbazolones with Arenesulphonyl Azides

2,9-Dimethyl-1,2,3,4-tetrahydro-1-oxo-β-carboline and 2,9-dimethyl-1,2,3,4-tetrahydro-β-carboline react with arenesulphonyl azides forming indoline-3-spiropyrrolidines; 2,10-dimethyl-3,4,5,10-tetrahydroazepinoindol-1(2H)-0ne and 2,10-dimethyl-1,2,3

3-FORMYL-2-PYRROLIDONE DERIVATIVES IN THE FISCHER REACTION

A method for the synthesis of 1-oxo-1,2,3,4-tetrahydro-β-carboline derivatives based on the Fischer reaction of 3-formyl-2-pyrrolidone derivatives with arylhydrazines is proposed.