20788-45-8

Upstream product

• 77928-09-7 ethyl α-methylthio-4-allyloxy-3-chlorophenylacetate 
• 324520-53-8 (4-allyloxy-3-chloro-phenyl)-ethylsulfanyl-acetic acid ethyl ester 
• 20788-42-5 allyl 2-chlorophenyl ether 

Downstream Products

• 22131-79-9 aclofenac 

Relevant academic research and scientific papers

Synthesis of ethyl arylacetates by means of Friedel-Crafts reactions of aromatic compounds with ethyl α-chloro-α-(ethylthio)acetate catalysed by ytterbium triflate

An efficient Friedel-Crafts alkylation of aromatic compounds with ethyl α-chloro-α-(ethylthio)acetate catalysed by ytterbium triflate, followed by desulfurisation of the product provides a convenient methodology for the synthesis of ethyl arylacetates of aromatic and heteroaromatic compounds. (C) 2000 Elsevier Science Ltd.

Synthesis of Ethyl Arylacetates by Means of Friedel-Crafts Reaction of Aromatic Compounds with Ethyl α-Chloro-α-(methylthio)acetate

Friedel-Crafts reaction of aromatic compounds with ethyl α-chloro-α-(methylthio)acetate (1) gave ethyl α-(methylthio)arylacetates (2), which were readily converted into ethyl arylacetates (3) by reductive desulfurization with Raney nickel or zinc dust-acetic acid.The reactions were applied to the syntheses of ibufenac (5) and alclofenac (6), which are anti-inflammatory agents.