2079-50-7Relevant academic research and scientific papers
4,6-Diphenylpyrimidine Derivatives as Dual Inhibitors of Monoamine Oxidase and Acetylcholinesterase for the Treatment of Alzheimer's Disease
Kumar, Bhupinder,Dwivedi, Ashish Ranjan,Sarkar, Bibekananda,Gupta, Sukesh Kumar,Krishnamurthy, Sairam,Mantha, Anil K.,Parkash, Jyoti,Kumar, Vinod
, p. 252 - 265 (2019)
Alzheimer's disease (AD) is a neurodegenerative disorder with multifactorial pathogenesis. Monoamine oxidase (MAO) and acetylcholinesterase enzymes (AChE) are potential targets for the treatment of AD. A total of 15 new propargyl containing 4,6-diphenylpy
Synthesis, characterization and antiamoebic activity of chalcones bearing N -substituted ethanamine tail
Leeza Zaidi, Saadia,Mittal, Sonam,Rajala, Maitreyi S.,Avecilla, Fernando,Husain, Mohammad,Azam, Amir
, p. 179 - 189 (2015/06/08)
A series of chalcones (4-21) possessing N-substituted ethanamine were synthesized by the aldol condensation reaction of 1-(4-(2-substituted ethoxy)phenyl)ethanones with different aldehydes preceded by the reaction of 2-chloro N-substituted ethanamine hydr
PHENYL-THIAZOLYL INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION
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Page/Page column 31, (2012/12/13)
This invention relates to phenyl thiazole I and its therapeutic and prophylactic uses, wherein the variables Rz, Q, J, R1, R3, R5, R6, and R7 are defined in the specification. Disorders treated and/or prevented include rheumatoid arthritis.
Novel imidazole derivatives, their preparation and their use as medicaments
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Page/Page column 9, (2008/06/13)
Novel imidazole compounds of the formula wherein the substituents are as defined in the application having antitumoral activity and use thereof.
Anethole dithiolethione and other dithiolethiones for the treatment of conditions associated with dysfunction of monoamine neruotransmission
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Page/Page column 6, (2008/06/13)
The present disclosure relates to dithiolethione derivatives as monoamino oxidase inhibitors, in particular MAO-B inhibitors, to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said dithiolethiones der
6-Aryl-4-methylsulfanyl-2H-pyran-2-one-3-carbonitriles as PPAR-γ activators
Sharon, Ashoke,Pratap, Ramendra,Vatsyayan, Rit,Maulik, Prakas R.,Roy, Uma,Goel, Atul,Ram, Vishnu Ji
, p. 3356 - 3360 (2007/10/03)
Various 6-aryl-3-cyano/methoxycarbonyl-4-methylsulfanyl-2H-pyran-2-ones have been synthesized as a potential substitute of 2,4-thiazolidinedione head group to express potent PPAR-γ transactivation response. Some of the screened compounds have shown promis
Synthesis, inhibitory activity towards human leukocyte elastase and molecular modelling studies of 1-carbamoyl-4-methyleneaminoxyazetidinones
MacChia, Bruno,Gentili, Daniela,MacChia, Marco,Mamone, Francesca,Martinelli, Adriano,Orlandini, Elisabetta,Rossello, Armando,Cercignani, Giovanni,Pierotti, Rita,Allegretti, Marcello,Asti, Cinzia,Caselli, Gianfranco
, p. 53 - 67 (2007/10/03)
Some monocyclic β-lactam derivatives of type 3 (MAOAs) in which the leaving group (LG) on the C(4) is a methyleneaminoxy moiety, were synthesised and tested in vitro and in vivo for their inhibitory activity towards human leukocyte elastase (HLE). Some compounds showed an appreciable in vitro inhibitory activity against this enzyme. Effects on the anti-HLE activity due to the nature of the substituents R and R1 present on their LG were observed and rationalised by means of molecular modelling techniques. The results of in vivo pharmacological tests indicated that MAOAs, while showing an inhibitory activity on the haemorrhage induced by HLE, did not exhibit any effects due to the R and R1 substituents. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
