207915-99-9

Basic information

• Product Name: CHLORO-N,N,N',N'-TETRAMETHYLFORMAMIDINIUM HEXAFLUOROPHOSPHATE
• Synonyms: CHLORO-N,N,N',N'-TETRAMETHYLFORMAMIDINIUM HEXAFLUOROPHOSPHATE;CHLORO-N,N,N,N-TETRAMETHYLFORMA-MIDINIUM PF6;Chloro-N,N,N',N'-tetramethylformamidiniumhexafluo;N,N,N',N'-Tetramethylchloroformamidinium-hexafluorophosphate;N-(Chloro(diMethylaMino)Methylene)-N-MethylMethanaMiniuM hexafluorophosphate(V);Chloro-N,N,N′,N′-tetraMethylforMaMidiniuM hexafluorophosphate, >=98.0%;TCFH N,N,N‘,N‘-Tetramethylchloroformamidinium-hexafluorophosphe;Chloro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate >=98.0% (T)
• CAS NO: 207915-99-9
• Molecular Formula: C5H12ClF6N2P
• Molecular Weight: 280.58
• EINECS: 1533716-785-6
• Product Categories: Coupling;Peptide Synthesis;Phosphonium/Uronium/Formamidinium;Phosphonium/Uronium/FormamidiniumSynthetic Reagents
• Mol File: 207915-99-9.mol
• Article Data: 0

Chemical Properties

• Melting Point: 99-104 °C
• Appearance: White to off-white/Powder
• Storage Temp.: 2-8°C
• Solubility: DMSO, Methanol
• BRN: 7896715
• CAS DataBase Reference: CHLORO-N,N,N',N'-TETRAMETHYLFORMAMIDINIUM HEXAFLUOROPHOSPHATE(CAS DataBase Reference)
• NIST Chemistry Reference: CHLORO-N,N,N',N'-TETRAMETHYLFORMAMIDINIUM HEXAFLUOROPHOSPHATE(207915-99-9)
• EPA Substance Registry System: CHLORO-N,N,N',N'-TETRAMETHYLFORMAMIDINIUM HEXAFLUOROPHOSPHATE(207915-99-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 3-10-21
• Hazardous Substances Data: 207915-99-9(Hazardous Substances Data)

Usage

Description

Chloro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate is a versatile reagent with a wide range of applications in various industries. It is known for its ability to act as a reactant in the synthesis of onium salts, which are used in peptide coupling, and as a safer alternative to traditional coupling reagents. Additionally, it is utilized in the synthesis of cancer cell cytotoxins and bioconjugation reagents.

Uses

Used in Pharmaceutical Industry:
Chloro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate is used as a reactant for the synthesis of onium salts for use in peptide coupling. This application is crucial in the development of new drugs and therapeutic agents, as peptide coupling is a key step in the synthesis of many bioactive peptides and peptidomimetics.
Used in Nuclear Industry:
In the nuclear industry, Chloro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate is used as a reagent for the synthesis of benzotriazole-based uranium reagent. This safer alternative to traditional coupling reagents helps to minimize the risks associated with handling hazardous materials in nuclear applications.
Used in Cancer Research:
Chloro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate is used as a reagent for the synthesis of cancer cell cytotoxins. These cytotoxins are essential in the development of new cancer treatments, as they can selectively target and kill cancer cells while minimizing damage to healthy cells.
Used in Bioconjugation:
Chloro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate is also used as a reagent for the synthesis of bioconjugation reagents. Bioconjugation is a technique used to attach biologically active molecules, such as antibodies or enzymes, to other molecules or surfaces. This process is vital in various applications, including drug delivery, diagnostics, and the development of biosensors.