207922-87-0Relevant academic research and scientific papers
Process research and scale-up for a β-3 adrenergic receptor agonist
Vanderplas, Brian C.,Devries, Keith M.,Fox, Darrell E.,Raggon, Jeffrey W.,Snyder, Michael W.,Urban, Frank J.
, p. 583 - 586 (2004)
A scaleable synthesis of the β-3 adrenergic receptor agonist, (4-{2-[2-(6-aminopyridin-3-yl)-(2R)-hydroxy-ethylamino]ethoxy}-phenyl)acetic acid is presented. The key coupling step utilizes a silyl-protected β-hydroxy tosylate to alkylate a primary amine,
