207986-60-5Relevant articles and documents
A new chiral lithium amide based on (S)-2-[1-(3,3- dimethyl)pyrrolidinylmethyl]pyrrolidine-synthesis, NMR studies and use in the enantioselective deprotonation of cyclohexene oxide
Khan, Agha Zul-Qarnain,De Groot, Rimke W.,Arvidsson, Per I.,Davidsson, Oejvind
, p. 1223 - 1229 (1998)
A new chiral lithium amide has been designed starting from (S)-proline. This new chiral lithium amide has been used for asymmetric deprotonation/ring opening of cyclohexene oxide to give (S)-2-cyclohexen-1-ol in 88% yield and 78% enantiomeric excess. NMR studies of the lithium amide and the ligand- substrate complex are also presented.