2080-77-5Relevant academic research and scientific papers
Total synthesis of (?)-haploscleridamine
Singha Roy, Moumita,Meng, Xiaofeng,Koda, Karuna,Rasapalli, Sivappa,Gout, Delphine,Lovely, Carl J.
, p. 979 - 982 (2019)
Asymmetric total synthesis of the imidazole containing β-carboline natural product, haploscleridamine, from histidine is described. Key to the successful assembly of this alkaloid is a ring-closing metathesis reaction of an imidazole derived allylic alcohol to construct a 3-piperidinone. Application of the Buchwald-modification of the classical Fischer indolization and deprotection of the N-tosyl moiety delivered haploscleridamine.
