208173-19-7

Basic information

• Product Name: 2-FLUORO-3-(TRIFLUOROMETHYL)BENZOYL CHLORIDE
• Synonyms: α,α,α,2-Tetrafluoro-m-toluoyl chloride;2-FLUORO-3-(TRIFLUOROMETHYL)BENZOYL CHLORIDE;alpha,alpha,alpha,2-Tetrafluoro-m-toluoyl chloride;2-Fluoro-3-(trifluoromethyl)benzoyl chloride, 97+%;à,à,à,2-tetrafluoro-m-toluoyl chloride;2-Fluoro-3-(trifluoromethyl)benzoyl chloride 97%
• CAS NO: 208173-19-7
• Molecular Formula: C₈H₃ClF₄O
• Molecular Weight: 226.56
• EINECS: 200-258-5
• Product Categories: Fluorobenzene;Miscellaneous;Acid Halides;Carbonyl Compounds;Organic Building Blocks
• Mol File: 208173-19-7.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 193 °C(lit.)
• Flash Point: 215 °F
• Appearance: /
• Density: 1.517 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.288mmHg at 25°C
• Refractive Index: n20/D 1.472(lit.)
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive: Moisture Sensitive
• BRN: 7992377
• CAS DataBase Reference: 2-FLUORO-3-(TRIFLUOROMETHYL)BENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-3-(TRIFLUOROMETHYL)BENZOYL CHLORIDE(208173-19-7)
• EPA Substance Registry System: 2-FLUORO-3-(TRIFLUOROMETHYL)BENZOYL CHLORIDE(208173-19-7)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 23-26-36/37/39-45
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 208173-19-7(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to yellow liquid

InChI:InChI=1/C8H3ClF4O/c9-7(14)4-2-1-3-5(6(4)10)8(11,12)13/h1-3H

Upstream product

• 392-85-8 1-fluoro-2-trifluoromethylbenzene 
• 115029-22-6 2-fluoro-3-(trifluoromethyl)benzoic acid 

Downstream Products

• 887289-52-3 C₁₉H₂₁F₄N₃O 
• 1070400-15-5 2-fluoro-N-(2-hydroxy-1,1-dimethylethyl)-3-(trifluoromethyl)benzamide 
• 207853-60-9 2-fluoro-3-(trifluoromethyl)benzamide 
• 123973-25-1 2-fluoro-3-(trifluoromethyl)aniline 
• 1222509-13-8 2-fluoro-N-(1-hydroxy-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-3-trifluoromethyl-benzamide 
• 1445949-60-9 6,6'-((4S,4'S)-4,4',5,5'-tetrahydro-4,4'-bioxazole-2,2'-diyl)bis(2-(trifluoromethyl)phenol) 
• 1445949-49-4 (4S,4'S)-2,2'-bis(2-(benzyloxy)-3-(trifluoromethyl)phenyl)-4,4',5,5'-tetrahydro-4,4'-bioxazole 
• 1445949-48-3 (4S,4'S)-2,2'-bis(2-fluoro-3-(trifluoromethyl)phenyl)-4,4',5,5'-tetrahydro-4,4'-bioxazole 
• 1445949-47-2 N,N'-((2S,3S)-1,4-dihydroxybutane-2,3-diyl)bis(2-fluoro-3-(trifluoromethyl)benzamide) 
• 1445949-46-1 N,N'-((2S,3S)-1,4-bis(benzyloxy)butane-2,3-diyl)bis(2-fluoro-3-(trifluoromethyl)benzamide) 
• 1395412-06-2 2-fluoro-N-methyl-N-(4-o-tolyl-pyridin-3-yl)-3-trifluoromethyl-benzamide 
• 1363453-99-9 2'-(4-(2-fluoro-3-(trifluoromethyl)benzamido)phenyl)-6-methyl-[2,6'-bibenzo[d]thiazole]-7-sulfonic acid 

Relevant articles and documents

2-chloro-3-fluoro-4-(trifluoromethyl) benzaldehyde and synthesis method thereof

The invention belongs to the technical field of pesticide intermediates, and particularly relates to 2-chloro-3-fluoro-4-(trifluoromethyl) benzaldehyde. The invention discloses unreported 2-chloro-3-fluoro-4-(trifluoromethyl) benzaldehyde and a synthetic method thereof. In the synthesis process, the product is formed through reaction under normal pressure, the process is simple, industrial application is facilitated, reaction conditions are mild, operation is easy, and the industrial production requirement is met; the 2-chloro-3-fluoro-4-(trifluoromethyl) benzaldehyde disclosed by the invention can be widely applied to a pesticide synthesis process, such as synthesis of pesticides such as herbicides and the like, and is relatively high in synthesis yield and relatively high in purity.

Novel quinazoline derivatives bearing various 6-benzamide moieties as highly selective and potent EGFR inhibitors

A series of novel quinazoline derivatives bearing various C-6 benzamide substituents were synthesized and evaluated as EGFR inhibitors, and most showed significant inhibitory potency against EGFR kinase. In particular, compound 6g possessed potent inhibitory activity against EGFR wild-type (IC50 = 5 nM), and strong antiproliferative activity against HCC827 and Ba/F3 (L858R) cell lines. Kinase profiling against a panel of 365 kinases showed that 6g was highly selective for EGFR. Furthermore, 6g showed desirable properties in assays of liver microsome metabolic stability and cytochromes P450 inhibition and preliminary pharmacokinetic study. The overall attractive profile of 6g made it an interesting compound for further development.

P2X7 MODULATORS

The present invention is directed to a compound of Formula (I) The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.