208253-22-9

Upstream product

• 157952-85-7 2-iodo-4,4-dimethyl-cyclohex-2-enone 
• 208253-08-1 2-(2-(trimethylsilyl)ethenyl)-3-methyl-2-cyclohexen-1-one 
• 1073-13-8 4,4-dimethylcyclohexenone 

Downstream Products

• 208253-23-0 (E)-2-(2-iodoethenyl)-4,4-dimethyl-2-cyclohexen-1-one 
• 208253-24-1 4-[(E)-4-(3,3-Dimethyl-6-oxo-cyclohex-1-enyl)-but-3-en-1-ynyl]-benzoic acid ethyl ester 

Relevant academic research and scientific papers

Phenylcyclohexene and phenylcyclohexadine substituted compounds having retinoid antagonist activity

Retinoids are natural and synthetic analoques of the hormone retinoic acid. Systemic retinoid agonist therapy is usually associated with toxic side effects, such as mucocutaneos toxicity, which may be alleviated by the use of topical retinoid antagonists. We report the synthesis and biological activity of a new series of potent, RAR-specific antogonists substituted with phenylcyclohexene and phenylcyclohexadiene groups.

ARYL-AND HETEROARYLCYCLOHEXENYL SUBSTITUTED ALKENES HAVING RETINOID AGONIST, ANTAGONIST OR INVERSE AGONIST TYPE BIOLOGICAL ACTIVITY

Compounds of the formula STR1 wherein the symbols have the meaning defined in the specification, have retinoid-like, retinoid antagonist or retinoid inverse agonist-like biological activity.