208254-41-5Relevant academic research and scientific papers
A series of C-terminal amino alcohol dipeptide Aβ inhibitors
Garofalo, Albert W.,Wone, David W.G.,Phuc, Angela,Audia, James E.,Bales, Cheryl A.,Dovey, Harry F.,Dressen, Darren B.,Folmer, Beverly,Goldbach, Erich G.,Guinn, Ashley C.,Latimer, Lee H.,Mabry, Thomas E.,Nissen, Jeffrey S.,Pleiss, Michael A.,Sohn, Stephen,Thorsett, Eugene D.,Tung, Jay S.,Wu, Jing
, p. 3051 - 3053 (2007/10/03)
Potent, small molecule Aβ inhibitors have been prepared that incorporate an alanine core bracketed by an N-terminal arylacetyl group and various C-terminal amino alcohols. The compounds exhibit stereospecific inhibition as demonstrated in an in vitro assa
Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis
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, (2008/06/13)
Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
Compounds for inhibiting β-amyloid peptide release and/or its synthesis
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, (2008/06/13)
Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis.
Compounds for inhibiting β-amyloid peptide release and/or its synthesis
-
, (2008/06/13)
Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis.
