208343-16-2Relevant academic research and scientific papers
Enantioselective catalysis, 120 [1]new optically active pyrrole-oxazolines
Brunner, Henri,Hassler, Bernd
, p. 476 - 480 (1998)
14 new optically active pyrrole-oxazolines were synthesised from 2-pyrrole-carbonitrile or methyl 2-pyrrole-carboximidate and chiral amino alcohols. Their use in copper-catalysed enantioselective cyclopropanation reactions gave only low optical yields (3-14%ee).
Enantioselective Addition of Diethylzinc to Aromatic Aldehydes Using Chiral Oxazoline-Based Ligands
Aydin, A. E.
, p. 1304 - 1312 (2020/10/02)
Abstract: Chiral oxazoline ligands containing an aromatic ring were prepared fromnorephedrine and pyrrole-2-carbonitrile or 2-hydroxybenzoyl chloride. Thesynthesized ligands were used in the copper-catalyzed asymmetric addition ofdiethylzinc to aromatic aldehydes to provide optically active 1-arylpropan-1-olswith high conversion (92%) and enantioselectivity (up to 99% ee).
Asymmetric Henry reactions catalyzed by metal complexes of chiral oxazoline based ligands
Ebru Aydin,Yuksekdanaci, Seda
, p. 14 - 22 (2013/02/23)
Chiral oxazolines have been synthesized from norephedrine and pyrrole nitrile or benzoyl chloride and applied to the catalytic asymmetric Henry reactions of p-nitro aldehydes with nitromethane to provide β-hydroxy nitroalkanols in high conversion (up to 92%). The reaction was then optimized in terms of the metal, solvent, temperature, and amount of chiral ligand. The corresponding catalyst with Cu(OTf)2 and isopropanol as the solvent gave the best enantioselectivities (up to 84% ee) of the corresponding β-nitroalkanol for p-nitrobenzaldehyde.
