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13-O-(Triethylsilyl) Baccatin III is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

208406-86-4

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208406-86-4 Usage

Chemical Properties

Off-White Solid

Uses

Protected Baccatin III. Paclitaxel - In House Impurity.

Check Digit Verification of cas no

The CAS Registry Mumber 208406-86-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,8,4,0 and 6 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 208406-86:
(8*2)+(7*0)+(6*8)+(5*4)+(4*0)+(3*6)+(2*8)+(1*6)=124
124 % 10 = 4
So 208406-86-4 is a valid CAS Registry Number.

208406-86-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-9-[(triethylsilyl)oxy]-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one

1.2 Other means of identification

Product number -
Other names 13-O-(Triethylsilyl) Baccatin III

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:208406-86-4 SDS

208406-86-4Relevant academic research and scientific papers

Orally active docetaxel analogue: Synthesis of 10-deoxy-10-C-morpholinoethyl docetaxel analogues

Iimura, Shin,Uoto, Kouichi,Ohsuki, Satoru,Chiba, Jun,Yoshino, Toshiharu,Iwahana, Michio,Jimbo, Takeshi,Terasawa, Hirofumi,Soga, Tsunehiko

, p. 407 - 410 (2007/10/03)

To improve cytotoxicity of 10-deoxy-10-C-morpholinoethyl docetaxel analogues against various tumor cell lines including resistant cells expressing P-glycoprotein (P-gp), we modified the 7-hydroxyl group to hydrophobic groups (methoxy, deoxy, 6,7-olefin, α-F, 7-β-8-β-methano, fluoromethoxy). Among these analogues, the 7-methoxy analogue showed the strongest cytotoxicity. This analogue showed potent activity against B16 melanoma BL6 in vivo by oral administration.

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