20841-80-9

Usage

Uses

Used in Pharmaceutical Synthesis:
2-Oxo-1-o-tolylpyrrolidine-3-carboxylic acid is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the formation of complex molecular structures.
Used in Agrochemical Production:
In the agrochemical industry, 2-Oxo-1-o-tolylpyrrolidine-3-carboxylic acid is used as a precursor in the production of various agrochemicals, helping to create compounds that can protect crops and enhance agricultural yields.
Used as a Building Block in Organic Chemistry:
2-Oxo-1-o-tolylpyrrolidine-3-carboxylic acid is utilized as a building block in organic chemistry, allowing for the creation of a wide range of organic compounds due to its versatile molecular structure.
Used as a Chiral Auxiliary in Asymmetric Synthesis:
Recognized for its potential as a chiral auxiliary, 2-Oxo-1-o-tolylpyrrolidine-3-carboxylic acid is used in asymmetric synthesis to facilitate the production of enantiomerically pure compounds, which are essential in various chemical and pharmaceutical applications.
It is important to handle 2-Oxo-1-o-tolylpyrrolidine-3-carboxylic acid with care and under proper safety precautions due to its potential hazards.

Upstream product

• 5617-70-9 cycl-isopropylidene cyclopropane-1,1-dicarboxylate 
• 95-53-4 o-toluidine 

Relevant academic research and scientific papers

Discovery of novel dual c-Met/HDAC inhibitors as a promising strategy for cancer therapy

Owing to the low efficacy and acquired resistance in clinical trials of c-Met inhibitors, based on the synergistic effects between c-Met and HDAC, novel c-Met and HDAC dual inhibitors were designed and synthesized. We introduced 2-pyrrolidinone to form the 5-atoms linker for c-Met inhibitor and hydroxamic acid as a zinc binding motif for HDAC inhibitor. The highly active dual inhibitor 15f showed excellent and balanced activity against both c-Met (IC50 = 12.50 nM) and HDAC1 (IC50 = 26.97 nM). In those tested tumor cell lines, 15f exhibits efficient antiproliferative activity with greater potency than Vorinostat (SAHA) and Cabozantinib (XL184). However, by comparing with an equimolar mixture of SAHA and Foretinib, we did not observe the compounds showed clearly synergistic antiproliferative effect. Nevertheless, compound 15f was found to induce apoptosis and cause cell cycle arrest in G2/M phase. This proof-of-concept study provides an efficient strategy for discovery of multitarget antitumor drugs.

INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES

This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative disorders, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, and disorders characterised by cytotoxic α-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such neurodegenerative disorders. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds.