208445-15-2Relevant academic research and scientific papers
Novel methodology for the preparation of 5-substituted tetrahydro[2,3- d]pyrimidines
Watson, Samuel E.,Taylor, Edward C.,Patel, Hemantkar
, p. 1897 - 1905 (2007/10/03)
A convenient, concise route for the preparation of tetrahydropyrido[2,3- d]pydmidines functionalized at the 5-position is presented starting from acyclic aldehydes. Key steps involve a high yielding Knoevenagel condensation, 1,4 conjugate addition with an
