20845-17-4

Basic information

• Product Name: (S)-Allyl 2-aMinopropanoate 4-Methylbenzenesulfonate
• Synonyms: (S)-Allyl 2-aMinopropanoate 4-Methylbenzenesulfonate;L-alanine allyl ester hydro-p-toluenesulfonate
• CAS NO: 20845-17-4
• Molecular Formula: C₆H₁₁NO₂*C₇H₈O₃S
• Molecular Weight: 301.35866
• Mol File: 20845-17-4.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: (S)-Allyl 2-aMinopropanoate 4-Methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-Allyl 2-aMinopropanoate 4-Methylbenzenesulfonate(20845-17-4)
• EPA Substance Registry System: (S)-Allyl 2-aMinopropanoate 4-Methylbenzenesulfonate(20845-17-4)

Safety Data

• Hazardous Substances Data: 20845-17-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(S)-Allyl 2-aMinopropanoate 4-Methylbenzenesulfonate is used as an antineoplastic agent for its potential to interfere with the growth of cancer cells and inhibit the activity of the enzyme dihydrofolate reductase.
Used in Organic Synthesis:
(S)-Allyl 2-aMinopropanoate 4-Methylbenzenesulfonate is used as a reagent in the synthesis of pharmaceuticals and other organic compounds, particularly due to the properties of its 4-Methylbenzenesulfonate component.

Upstream product

• 56-41-7 L-alanin 
• 104-15-4 toluene-4-sulfonic acid 
• 107-18-6 allyl alcohol 

Downstream Products

• 113370-86-8 allyl 2-methyl-6,8-dioxo-4,7-diphenyl-3,7-diazabicyclo<3.3.0>octane-2-carboxylate 
• 121637-88-5 (S)-2-{(S)-3-Hydroxy-2-[(S)-2-(2-nitro-phenylsulfanylamino)-propionylamino]-propionylamino}-propionic acid allyl ester 
• 113370-59-5 allyl N-benzylidenealaninate 
• 116912-14-2 N-(Phenylacetyl)-L-isoleucyl-L-alanin-allylester 
• 88224-19-5 N-Benzyloxycarbonyl-L-phenylalanyl-L-alanin-allylester 

Relevant articles and documents

Crystallization-induced asymmetric transformations. Enantiomerically pure (-)-(R)- and (+)-(S)-2,3-dibromopropan-1-ol and epibromohydrins. A study of dynamic resolution via the formation of diastereoisomeric esters

(S)-2,3-Dibromopropan-1-ol of high enantiomer excess was obtained by crystallization-induced asymmetric transformations of racemic 2,3-dibromopropan-1-ol esterified with N-([1,1′-biphenyl]-4-ylcarbonyl-L-alanine; in particular, an asymmetric transformatio

Mild and highly chemoselective oxidation of thioethers mediated by Sc(OTf)3

(Matrix presented) Catalytic Sc(OTf)3 greatly increases the efficiency of hydrogen peroxide mediated monooxidation of alkyl-aryl sulfides and methyl cysteine containing peptides. The method is high yielding, compatible with many widely used protecting groups, suitable for solid-phase applications and proceeds with minimum over-oxidation.

Allyl Esters as Selectively Removable Carboxy-protecting Functions in Peptide and N-Glycopeptide Syntheses

Allyl esters are advantageous in protection of the carboxylic function in peptide and glycopeptide syntheses and can easily be synthesized from amino acids.They are stable under acidic conditions used for the removal of the Boc and Z groups.Under neutral or weakly basic conditions allyl esters are cleaved smoothly on treatment with catalytic amounts of tris(triphenylphosphane)rhodium(I) chloride in ethanol/water (9:1) leaving the N-protecting function and the N-glycosidic bond untouched.Selective deblocking of the α-carboxylic function of protected N-glycosylated asparagine derivatives 15 carried out in this way is exploited in C-terminal chain extension in the synthesis of N-glycotripeptides 17,e.g 17c, the latter representing a partial sequence of a human immunoglobulin G1.