208510-17-2

Upstream product

• 208510-20-7 (2S,5R)-5-allyl-5-(2-bromoallyl)-2,5-dihydro-3,6-dimethoxy-2-isopropylpyrazine 
• 208510-18-3 (2R,5S)-2-Allyl-5-isopropyl-3,6-dimethoxy-2-prop-2-ynyl-2,5-dihydro-pyrazine 
• 138892-18-9 (2S,5R)-5-allyl-2,5-dihydro-3,6-dimethoxy-2-isopropylpyrazine 
• 208510-10-5 (3S,6R)-3-Isopropyl-2,5-dimethoxy-10-methylene-1,4-diaza-spiro[5.5]undeca-1,4,8-triene 

Relevant academic research and scientific papers

Cyclic α-Amino Acids by Pd-mediated Cycloisomerization and Coupling Reactions

Stereoselective syntheses of cyclic α-amino acids are described.The α-carbon of the amino acid is incorporated into a five- or six-membered vicinal dimethylenecycloalkane or conjugated methylenecycloalkene.Palladium-catalysis was used for cycloisomerization of intermediate enynes and intramolecular Heck type cyclizations of bromoindenes.A stereoselective elimination from a homoallylic Pd-intermediate is described.Enantiomerically pure substrates for the cyclization reactions were available by stepwise alkylations of the chiral auxiliary (R)-2,5-dihydro-3,6-dimethoxy-2-isopropylpyrazine with bromo-alkenes and -alkynes.