208512-75-8

Upstream product

• 7587-15-7 2,3-dichloro-4-iodophenol 
• 583-78-8 2,5-dichlorophenol 
• 208512-74-7 dimethyl-thiocarbamic acid O-(2,5-dichloro-4-iodo-phenyl) ester 

Downstream Products

• 208512-76-9 2,3-dichloro-4-iodothiophenol 
• 208512-83-8 (6R,7R)-7-{2-[4-((E)-2-Carboxy-vinyl)-2,5-dichloro-phenylsulfanyl]-acetylamino}-3-chloromethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 307002-20-6 2-({4-[(1E)-2-{[2-(tert-butoxy)-2-oxoethyl]carbamoyl}eth-1-en-1-yl]-2,5-dichlorophenyl}sulfanyl)acetic acid 
• 208512-49-6 {4-[2-(tert-butoxycarbonylmethyl-carbamoyl)-vinyl]-2,5-dichloro-phenylsulfanyl}-acetic acid methyl ester 
• 208512-47-4 (E)-3-(2,5-Dichloro-4-methoxycarbonylmethylsulfanyl-phenyl)-acrylic acid 2,5-dioxo-pyrrolidin-1-yl ester 
• 208512-43-0 3-(2,5-dichloro-4-methoxycarbonylmethylsulfanyl-phenyl)-acrylic acid tert-butyl ester 
• 208512-39-4 3-(4-carboxymethylsulfanyl-2,5-dichloro-phenyl)-acrylic acid tert-butyl ester 
• 208512-45-2 (E)-3-(2,5-Dichloro-4-methoxycarbonylmethylsulfanyl-phenyl)-acrylic acid 
• 208512-77-0 (2,5-dichloro-4-iodo-phenylsulfanyl)-acetic acid methyl ester 

Relevant academic research and scientific papers

A high temperature investigation using microwave synthesis for electronically and sterically disfavoured substrates of the Newman-Kwart rearrangement

Electronically deactivated and/or sterically hindered substrates undergo the Newman-Kwart rearrangement (NKR) at around 300 °C, beyond the range of most convenient and safe, small-scale laboratory equipment. We report here the convenient conversions of several difficult substrates using modern microwave technology, which has proven ideal for investigating this high temperature reaction in all but the?most refractory of cases. In addition, several previously reported difficult examples were re-investigated, and found not to require high temperatures under these conditions, for various reasons which are elaborated upon.

Anti-MRSA cephems. Part 2: C-7 cinnamic acid derivatives

Forty-five novel cephalosporin derivatives with activity against methicillin-resistant Staphylococcus aureus (MRSA) are described. The compounds contain novel cinnamic acid moieties at C-7 that were synthesized using a key Heck reaction followed by nucleophilic aromatic substitution reactions. The most active compound (41) displayed an MIC90 against MRSA of 1.0 μg/mL, and a PD50 of 0.8 mg/kg. Compound 14 was found to be very safe in a mouse model of acute toxicity.